Symptom Profiles And Clinical Correlates Of Paranoid Schizophrenia In Vietnamese Patients
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Abstract
Aim: Paranoid schizophrenia presents diverse clinical features, and the factors contributing to this heterogeneity are not well understood, particularly in the Vietnamese population. We hypothesized that Vietnamese patients with paranoid schizophrenia would exhibit a high prevalence of auditory hallucinations and delusions, with varying content, behavioral impact, and temporal occurrence. Significant associations and predictors of specific symptom domains were anticipated.
Methods: This prospective study included 230 Vietnamese patients diagnosed with paranoid schizophrenia according to ICD-10 criteria. Patients were assessed for the presence, content, behavioral impact, and temporal occurrence of auditory hallucinations, delusions, thought form disorders, mood disorders, volitional activity disorders, and negative symptoms using structured questionnaires. Associations between demographic, clinical, and symptom-related characteristics were analyzed using appropriate statistical methods, and multivariate linear regression identified independent predictors of specific symptom domains.
Results: Auditory hallucinations and delusions were highly prevalent, with commenting voices (79.1%) and persecutory delusions (87.0%) being the most common. The content of these symptoms was more likely unreal than real. Age, illness duration, and the number of auditory hallucinations were significantly correlated with specific symptom domains. The number of concurrent auditory hallucinations and illness duration emerged as independent predictors of mood disorders and negative symptoms, respectively.
Conclusion: This study provides novel insights into the clinical heterogeneity of paranoid schizophrenia in Vietnamese patients, highlighting the importance of considering interrelationships between symptom domains. Identifying specific predictors for mood disorders and negative symptoms underscores the need for targeted interventions in this population.
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References
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