Assessment of Role of Probiotics in the Management of Parkinson’s Disease: A Meta-Analysis
Main Article Content
Abstract
Background: Conventional treatments are related with several difficulties, including dyskinesia, excessive daytime sleepiness, sudden sleep attacks, leg swelling, and discoloration. Therefore, we examine the efficacy of the probiotics in the management of Parkinson’s disease (PD).
Methodology: A widespread literature search was accomplished on PubMed, Google Scholar, Wiley as well as Nature of Science databases, covering the period since 2013 to 2023.
Result: A Total 13 studies were comprised in this study. This study shows high quality indication of development in undefined PD rating scale (UPDRS) (Standardize mean difference -1.00 [95% CI -4.07 to 2.07], NMSQ score -4.94 [95% CI -6.95 to -2.92],Quality of life QOL-45.95 [95% CI -52.05 to -39.86],Depression scale -4.57 [95% CI -8.40 to -0.74] as well as Bowel movement (BM)0.40 [95% CI -0.51 to 1.31].However there is significance found in the Bristol stool score in the placebo group.
Conclusion: Based on the study findings, it can be inferred that probiotics have a beneficial impact on non-motor symptoms, motor function, bowel movement as well as the reduction of depression in individuals with PD. The integration of probiotic supplementation into PD management has the potential to be a cheap and secure complementary treatment option.