Oxidative Stress and Antioxidant Therapies Balancing Cellular Equilibrium

Abstract

Objective: The purpose of this study was to evaluate the effectiveness of antioxidant therapy in reducing cellular damage caused by oxidative stress and enhancing clinical parameters in a group of one hundred patients at a tertiary care facility.

Methods: A trial with 100 participants was carried out that was double-blind, randomized, and placebo-controlled. A placebo was given to the control group and Vitamin C was given to the intervention group. Oxidative stress markers were measured at baseline and at different points during the course of the trial. These markers included lipid peroxidation products, antioxidant enzyme activity, and levels of oxidative DNA/protein damage markers. Additionally assessed were clinical characteristics including blood pressure and metabolic profiles.

Results: Compared to the control group, the intervention group showed significantly lower levels of oxidative stress markers, as evidenced by a drop in lipid peroxidation products and a reduction in oxidative damage to DNA and proteins. Furthermore, the intervention group exhibited increases in the activity of antioxidant enzymes. Positive changes in blood pressure, lipid profiles, and inflammatory markers were observed in the intervention group receiving the specific antioxidant therapy, indicating potential improvements in cardiovascular health and oxidative stress status compared to the control group. These findings suggest a favorable impact of the antioxidant intervention on key clinical parameters associated with oxidative stress-related conditions.

Conclusion: In summary, antioxidant therapy has the potential to improve clinical parameters and mitigate cellular damage caused by oxidative stress. These results highlight the need for additional study to identify the most effective therapeutic approaches and point to the potential value of antioxidant therapies as adjuvant therapy in diseases marked by oxidative stress.