Protein Aggregation Diseases: Unraveling Molecular Pathways for Intervention

Abstract

Protein aggregation illnesses, which include neurodegenerative conditions such as Alzheimer's, Parkinson's, and Huntington's, are caused by abnormal protein folding and aggregation, which results in both neurotoxicity and cellular dysfunction. Comprehending the molecular nuances of these ailments is essential for formulating focused therapies. The processes underlying protein misfolding, aggregation, and associated neurodegenerative effects are examined in this review. Clarified are molecular chaperones, imbalanced proteostasis, hereditary variables, and treatment approaches aimed at these pathways. A thorough understanding of possible remedies is offered by insights into gene-based techniques, protein clearance improvement tactics, immunotherapies, and small molecule inhibitors. By addressing these pathways, protein aggregation illnesses may be mitigated and the burden of these debilitating conditions may be lessened through the prospect of successful treatments.