Development And Validation Of Uv Spectrophotometeric Technique For Estimation Of Rosuvastain Drug In Bulk And Pharmaceutical Dosage Form
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Abstract
Objectives: The goal of this study is to create and test a UV-Spectrophotometric method for estimating Rosuvastatin in bulk and pharmaceutical dosage forms utilizing a green solvent.
Method: Development of UV-Spectrophotometric method was carried out by using 2.5% Sodium citrate solution as green solvent. Rosuvastatin was detected at a wavelength of 229nm. According to ICH guidelines, the developed technique was verified in terms of linearity, precision, accuracy, and robustness. Rosuvastatin in pharmaceutical dose forms was successfully estimated using a newly developed and verified approach.
Results: Rosuvastatin has a maximum absorption wavelength of 229nm. In the concentration range of 5-20µg/ml, Beer’s law was fallowed the recovery of Rosuvastatin Calcium in tablet form was found to be between 97 and 102 percent.
Conclusion: The method was found to be simple, environment friendly, reproducible and economical and can be used for routine analysis of Rosuvastatin in bulk and pharmaceutical dosage form. The 2.5% Sodium citrate solution can be used as green solvent.
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Vishal V. Rajkondwar, Pramila Maini1 and Monika Vishwakarma 21IEHE, Bhopal 2NRI Institute of Info. Sci. & Tech, Bhopal.