Synthesis Of Indole Novel Derivatives And Their Importance In Medicine
Main Article Content
Abstract
The indoles occurring naturally and synthetic have a diverse range of biological activities. Among their natural derivatives, unusual and complicated molecular structures are found. The international chemical community continues to pay attention to this significant ring system as a result, and novel approaches to creating this heteroaromatic ring, which is constantly relevant, are currently being researched. This paper introduce novel derivative of indole. The synthesis pathway are scalable and obtained high yield and purity.
Article Details
References
R. J. Sundberg, The Chemistry of Indoles, Academic Press, New York, 1970; R. J. Sundberg, Indoles, Academic Press, London, 1996; G. W. Gribble, J. Chem. Soc., Perkin Trans.
P. M. Jackson and C. J. Moody, J. Chem. Soc., Perkin Trans. 1, 1990, 2156–2158.
E. Vedejs and S. D. Monahan, J. Org. Chem., 1997, 62, 4763–4769.
Synthesis and characterisation of novel derivative of 2fluoro adenosine.(2022). journal of pharmaceutical negative results, 7726-7729.
Asati, N., & Yadava, R. N. (2017). Antibacterial activity of a triterpenoid saponin from the stems of Caesalpinia pulcherrima Linn. Natural Product Research, 32(5), 499–507.
Kumar A, Garg V, Chaudhary A, Jain PK, Tomar PK. 2014. Isolation, characterisation and antibacterial activity of new compounds from methanolic extract of seeds of Caesalpinia crista L. (Caesalpinaceae). Nat Prod Res. 28:230–238
Kar B., Kumar Suresh R. B., Karmakar I.,Dola N.,Bala A.,Mazumder U. K., Hadar P.K., Asian Pacific J. of Tropical Biomedicine ,976-980,( 2012).
Ravi Shankar K., Vineela P. D., Vaidehi B.N.B., Synthesis, International J. Of Biological & Pharmaceutical Research, 4(12),862-87, (2013).
Harborne JB. 1965. Plant polyphenols—XIV. Phytochemistry. 4:107–120.
Hirst EL, Jones JKN. 1949. 359. Quantitative analysis of mixture of sugars by the method of partition chromatography. Part III. Determination of the sugars by oxidation with sodium periodate. J Chem Soc. 1659–1661.
Kuhn R, Trischmann H, Löw I. 1955. Zur Permethylierung von Zuckern und Glykosiden. Angewandte Chemie. doi:10.1002/ange.19550670108.