Acute And Subacute Oral Toxicity Of Saraca Asoca In Rats
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Abstract
Ashoka is one of India's most revered and mythical trees. Some information regarding its potential toxicity is available. This study assessed Saraca asoca's acute and subacute toxicity in wistar rats. The mice were observed for 28 days after being given three separate doses of the plant orally for the acute and subacute toxicity. Result indicates no significant changes in body temperature, body weight and food and water consumption when compared to control group. No significant changes were observed in the relative organ weights of vital organs such as liver, lung, heart, spleen, kidney, brain and uterus with ovary as compared with control group. Body temperature of the rats of both sexes treated with SA Extract at doses low dose (250mg/kg), Intermediate dose (500mg/kg) and high dose (1000mg/kg) were not significantly different from control. When compared to the control groups, the current toxicity investigations of oral administration of SA bark extract (at dosages of 250, 500, and 1000 mg/kg) showed substantial alterations in physical, hematological, and biochemical parameters. Bark extract of SA administration may be hemolytic.
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References
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