A Comparative Study Of Mineral Micronutrients And Vitamin B12 In Psychotic Patient
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Abstract
Anemia is a condition where red blood cell (RBC) count and haemoglobin (HBG) concentration are lower than the reference range, which results as a decrease in the oxygen-carrying capacity, Following a compromise the physiological needs.
Along with the Decrease HBG concentration and haematocrit (HCT) RBC count, mean corpuscular volume (MCV), reticulocyte count, examination of blood film, and HBG electrophoresis are significant parameters for the diagnosis of anemia.
India is a common hub for megaloblastic anemia with prevalence range of 2-40%. Nutritional deficiency of either cobalamin (vitamin B12) or folate (vitamin B9) are commonest causes of Megaloblastic anemia.
This is case control analytical study carried out on 50 diagnosed Psychotic Patient as per the International Classification of diseases, Tenth revision (ICD-10). The study was conducted in Psychiatry department of Mahatma Gandhi Medical College & Hospital, Jaipur. Fifty age and sex matched healthy individuals constituted the control group. Our study found low levels of vitamin B12 and hemoglobin in psychotic patients. which might contribute to the psychosis symptoms
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References
Romain M, Sviri S, Linton D, Stav I, van Heerden PV. The role of vitamin B12 in the critically ill—a review. Anaesth Intensive Care. 2016;44 (4):447–452. doi:10.1177/0310057X16044004102.
Watanabe F, Bito T. Vitamin B12 sources and microbial interaction. Exp Biol Med. 2018;243(2):148–158. doi:10.1177/15353702177466123.
Allen LH, Miller JW, De Groot L, et al. Biomarkers of Nutrition for Development (BOND): vitamin B-12 review. J Nutr. 2018;148 (suppl_4):1995S–2027S. doi:10.1093/jn/nxy2014.
Kaur N, Nair V, Sharma S, Dudeja P, Puri P. A descriptive study of clinico-hematological profile of megaloblastic anemia in a tertiary care hospital. Med J Armed Forces India. 2018;74(4):365–370. doi:10.1016/j.mjafi.2017.11.0055.
Hariz A, Bhattacharya PT. Megaloblastic Anemia. StatPearls [Internet]; 2020.
Goossen LH. Anemias caused by defects of DNA metabolism. In: Rodak’s Hematology-E-Book: Clinical Principles and Applications. Elsevier Health Sciences; 2019:282.7.
Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24:105–131. doi:10.1146/ annurev.nutr.24.012003.1323068.
Obeagu EI, Babar Q, Obeagu GU. Megaloblastic anaemia-a review. Int J Curr Res Med Sci. 2021;7(5):17–24.9.
Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5–14.10.
Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients–a retrospective file review. Nord J Psychiatry. 2017;71(7):509–512. doi:10.1080/08039488.2017.134051711.
Akıl E, Bulut A, Kaplan İ, Özdemir HH, Arslan D, Aluçlu MU. The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson’s disease. Neurol Sci. 2015;36(3):423–428. doi:10.1007/s10072-014-1976-112.
Rembach A, Watt AD, Wilson WJ, et al. An increased neutrophil–lymphocyte ratio in Alzheimer’s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. J Neuroimmunol. 2014;273(1–2):65–71. doi:10.1016/j.jneuroim.2014.05.00513.
Abacioglu OO. Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse? Bratisl Lek Listy. 2020;121(2):151–153. doi:10.4149/BLL_2020_02114.
Canpolat U, Çetin EH, Cetin S, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation. Clin Appl Thromb Hemost. 2016;22(5):476–482. doi:10.1177/107602961559400215.
Kaplan I, Kaplan M, Abacioglu O, Yavuz F, Saler T. Monocyte/HDL ratio predicts hypertensive complications. Bratisl Lek Listy. 2020;121 (2):133–136. doi:10.4149/BLL_2020_01816.
Topal E, Celiksoy MH, Catal F, Karakoç H, Karadağ A, Sancak R. The Platelet Parameters as Inflammatory Markers in Preschool Children with Atopic Eczema. Clin Lab. 2015;61(5–6):493–496. doi:10.7754/Clin.Lab.2014.14093017.
Ataoglu A, Canan F. Mean platelet volume in patients with major depression: effect of escitalopram treatment. J Clin Psychopharmacol. 2009;29 (4):368–371. doi:10.1097/JCP.0b013e3181abdfd7
Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H. Major depressive disorder is associated with elevated monocyte counts. Acta Psychiatr Scand. 1996;94(3):198–204. doi:10.1111/j.1600-0447.1996.tb09849.x19.
Yüksel RN, Ertek IE, Dikmen AU, Göka E. High neutrophil-lymphocyte ratio in schizophrenia independent of infectious and metabolic parameters. Nord J Psychiatry. 2018;72(5):336–340. doi:10.1080/08039488. 2018.145889920.
Kirlioglu S, Balcioglu Y, Kalelioglu T, Erten E, Karamustafalioglu N. Comparison of the complete blood count-derived inflammatory markers in bipolar patients with manic and mixed episodes. Clin Study. 2019;195:199.21.
Ragolsky M, Shimon H, Shalev H, Weizman A, Rubin E. Suicidal thoughts are associated with platelet counts in adolescent inpatients. J Child Adolesc Psychopharmacol. 2013;23(1):49–53. doi:10.1089/cap.2012.005722.
Varsak N, Aydin M, Ibrahim E. The evaluation of neutrophil-lymphocyte ratio in patients with first episode psychosis. Family Practi Palliative Care. 2017;1(3):65–69. doi:10.22391/920.28741123.
Dogan M, Ariyuca S, Peker E, et al. Psychotic disorder, hypertension and seizures associated with vitamin B12 deficiency: a case report. Hum Exp Toxicol. 2012;31(4):410–413. doi:10.1177/096032711142240424.
Payinda G, Hansen T. Vitamin B12 deficiency manifested as psychosis without anemia. Am J Psychiatr. 2000;157(4):660–661. doi:10.1176/appi. ajp.157.4.660
Rajkumar A, Jebaraj P. Chronic psychosis associated with vitamin B12 deficiency. J Assoc Physicians India. 2008;56:115–116.
Jombo HE, Ekwere TA. A cross-sectional study of the impact of antipsychotic medications on the hematological profile of patients with schizophrenia in a tertiary health facility in Uyo, South-South, Nigeria. Int Neuropsychiatr Dis J. 2018;11(2):1–9. doi:10.9734/INDJ/2018/40894