Studies On Cocrystallization Of Pitavastatin: Solid State Characterization
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Abstract
The poor solubility and dissolution rate is major constrain in oral delivery of most of drugs. The most of drug synthesized nowadays are BCS class II and IV drugs. Many scientific investigators have utilized various approaches for dissolution rate enhancement of drug. The formulation of cocrystals is recently explored way for solubility enhancement of drug. Pitavstatin is HMG CoA reductase inhibitor used in management of increased cholesterol level. The poor solubility is major limitation associated with oral delivery of pitavastatin. Thus, present study has planned to formulate pitavastatin cocrystals.
The cocrystals of pitavastatin were prepared using various coformer by solvent evaporation method. The formulated cocrystals showed enhanced saturation solubility than pure drug and more drug release than pure drug. Thus, cocrystals could be promising alternative for delivery of drug.
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References
Aakeroy, C. B.; Seddon, K. R. The Hydrogen Bond and Crystal Engineering. Chem. Soc. Rev. 1993, 22 (Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved.), 397–407.
Aakeröy, C. B. Constructing Co-Crystals with Molecular Sense and Supramolecular Sensibility. Acta Crystallogr. Sect. A Found. Crystallogr. 2006, 62 (a1), s75–s75.
Aakeröy, C. B.; Hussain, I.; Desper, J. 2-Acetaminopyridine: A Highly Effective Cocrystallizing Agent. Cryst. Growth Des. 2006, 6 (2), 474–480.
Blagden, N.; de Matas, M.; Gavan, P. T.; York, P. Crystal Engineering of Active Pharmaceutical Ingredients to Improve Solubility and Dissolution Rates. Adv. Drug Deliv. Rev. 2007, 59 (7), 617–630.
Chadha, R.; Arora, P.; Saini, A.; Bhandari, S. Crystal Forms of Anti-HIV Drugs : Role of Recrystallization. Recrystallization 2012, 18.
Devarajan, P. V; Sonavane, G. S. Preparation and in Vitro/in Vivo Evaluation of Gliclazide Loaded Eudragit Nanoparticles as a Sustained Release Carriers. Drug Dev. Ind. Pharm. 2007, 33 (2), 101–111.
Frijlink, H. W.; Eissens, A. C.; Hefting, N. R.; Poelstra, K.; Lerk, C. F.; Meijer, D. K. F. The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the Rat. Pharm. Res. An Off. J. Am. Assoc. Pharm. Sci. 1991, 8 (1), 9–16.
Fukte, S. R.; Wagh, M. P.; Rawat, S. Coformer Selection: An Important Tool in Cocrystal Formation. Int. J. Pharm. Pharm. Sci. 2014, 6 (7), 9–14.
Galek, P.; Pidcock, E.; Wood, P. CSD Solid Form Suite : Addressing Key Issues in Solid State Development. Ccdc 2011, 1–16.
Giovanna Bruni , mariarosa Maietts, Lauretta Maggi, Pi. M. An Experimental and Theoretical Investigation of Loperamide Hydrochloride−Glutaric Acid Cocrystals. J. Phys. Chem. 2013, No. 117, 8113–8121.
Good, D. J.; Nair, R. H. Solubility Advantage of Pharmaceutical Cocrystals. Cryst. Growth Des. 2009, 9 (5), 2252–2264.
Chadha, R.; Rani, D.; Goyal, P. Novel Cocrystals of Gliclazide: Characterization and Evaluation. CrystEngComm 2016.
Childs, S. L.; Chyall, L. J.; Dunlap, J. T.; Smolenskaya, V. N.; Stahly, B. C.; Stahly, G. P.; Kent, A. V; Lafayette, W.; Road, B. Crystal Engineering Approach To Forming Cocrystals of Amine Hydrochlorides with Organic Acids . Molecular Complexes of Fluoxetine Hydrochloride with Benzoic , Succinic , and Fumaric Acids. 2004, No. 2, 13335–13342.
Childs, S. L.; Rodríguez-Hornedo, N.; Reddy, L. S.; Jayasankar, A.; Maheshwari, C.; McCausland, L.; Shipplett, R.; Stahly, B. C. Screening Strategies Based on Solubility and Solution Composition Generate Pharmaceutically Acceptable Cocrystals of Carbamazepine. CrystEngComm 2008, 10 (7), 856–864.
Desai, H.; Rao, L.; Amin, P. Carbamazepine Cocrystals by Solvent Evaporation Technique : Formulation and Characterization Studies. 2014, 4 (20. 124-129