Exploring Determinants of Infertility Among Women Aged 30-40 Years In South Asia: A Systemic Review

Abstract

This article focuses on the diagnosis and treatment of numerous underlying reasons for female infertility, as well as how age influences the outcomes of IVF and ICSI cycles. An analysis of 2511 cycles completed between January 1995 and June 1991 revealed that the participants' average age was 34 years. Interestingly, 45.9% of the population was between 30 and 35, 24.5% was between 36 and 39, and 7.1% was over 39. Follicle-stimulating hormone (FSH) blood concentrations on day 3 were less than 20 IU/l in all patients aged 40 and up. The stimulation treatments included the use of human menopausal gonadotropin (hMG), FSH, clomiphene citrate (CC), and gonadotropin-releasing hormone agonists (GnRHa). The study revealed a considerable correlation between age, rates of stimulation, and fertilisation failure. Due to this clinical pregnancy and embryo implantation rates fell to 12.8%, and 7.4%, respectively, among women over the age of 40. The rate of spontaneous abortion increased by 33.2% as people became older. Although clinical pregnancy rates per transfer were optimistic, 'take-home baby' rates in women 40 years of age and older fell to roughly 7% per cycle due to stimulation discontinuance and spontaneous abortions. The study shows that maternal age has a considerable impact on IVF and ICSI outcomes.