Formulation And Evaluation Of Polyherbal Anti-Inflammatory Gel
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Abstract
Inflammation is a very complex process and its pain affects millions of people worldwide. Approximately, 1-2% of the world population is affected by various inflammatory disorders and among them, women are three times more prone to the disease as compared to men. The present study was carried out to formulate and evaluate polyherbal gel formulation containing extracts of Curcuma amada and Nyctanthes arbortristis using carbopol-980 as gelling agents. Total six batches (F1to F6) were prepared and evaluated for physicochemical characteristics such as pH, viscosity, spreadability and drug content which were found within the range. All prepared formulations indicated good physical stability. In-vitro drug diffusion studies of formulations were performed by using Franz diffusion cell which shown percentage of total flavonoid release was 35.84% and percentage of total phenol release was 38.25 % for F5 batch formulation in five hours. The exvivo permeation study was carried out for optimized formulation using goat abdomen skin as barrier and shown percentage flavonoid release of 35.86 % and percentage phenol release of 27.32 % in F5 batch formulation in five hours. The antiinflammatory activity was conducted by using carrageenan induced rat paw edema model. The prepared formulation shown good inhibitory effect. From the results, we concluded that the polyherbal gel formulation of herbal drug Curcuma amada and Nyctanthes arbortristis have been found to be effective for treating inflammation.
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References
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