Investigating the Wound Healing Perspectives of Silver Nanoparticles Loaded Topical Nanogels

Abstract

The primary objective of the present investigation revolves around the development and evaluation of nanogel formulations by incorporating oleanolic acid-loaded silver nanoparticles. The formulation underwent a comprehensive assessment to evaluate its therapeutic attributes and topical delivery. The formulation was prepared by using carbopol 940 and triethanolamine. The parameters were analyzed as pH 5.5, viscosity 3500 cps, spreadability 6.9 g/cm/sec, and skin irritation tests showed no skin rashes. Ex-vivo drug release shows a slow release of the drug. There was 84.66% drug release in 12 hours. Additionally, Swiss albino rats were employed in this research to investigate the wound-healing capabilities of topical gel containing silver nanoparticles. Stability studies of the nanogel formulation were done. The results confirmed the spherical shape and uniform particle size of silver nanoparticles and the good stability of the nanogel. This study has provided a way for novel approaches to address wounds of various origins. The formulated topical gels loaded with silver nanoparticles exhibit promising prospects as wound healing agents. They are anticipated to enhance the natural wound healing process significantly and play a pivotal role in rat wound closure rate and epithelization. In comparison to the standard pharmaceutical agent betadine, the nanogel formulation exhibited equivalent efficacy. This discovery sheds light on the potential applications of nanoparticle-infused formulations in the conventional management of severe wound conditions, thereby revitalizing therapeutic principles within the field of modern medicine.