Formulation And Evaluation Of Diosgenin Gel For Its In Vivo Anti-Skin Cancer Activity
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Abstract
Cancer remains a significant global health burden, spurring relentless efforts in pharmaceutical research to discover effective therapeutic interventions. In this pursuit, natural compounds have garnered considerable attention for their potential anti-cancer properties. Diosgenin, a steroidal sapogenin found in various plant sources, has emerged as a promising candidate due to its diverse pharmacological activities, including anti-inflammatory, anti-diabetic, and notably, anti-cancer effects. Despite Diosgenin's potential, its clinical translation faces challenges related to poor aqueous solubility, low bioavailability, and rapid metabolism. To address these limitations and harness the full therapeutic potential of Diosgenin against cancer, advanced drug delivery systems are being explored. Microspheres, tiny spherical particles ranging from a few micrometers to millimeters in size, provide a versatile platform for drug encapsulation. By encapsulating Diosgenin within microspheres, a controlled release profile can be achieved, ensuring sustained exposure to therapeutic levels. This study aims to formulate and evaluate a Diosgenin-loaded microsphere gel for its in vivo anti-cancer activity. Through meticulous formulation design and comprehensive evaluation, we seek to elucidate the therapeutic potential of this novel delivery system in combating cancer. By bridging the gap between Diosgenin's bioactivity and its clinical application, we aspire to contribute to the advancement of cancer therapeutics and improve patient outcomes.
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References
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