Polyherbal Nanogel: A Potential Remedy For The Management Of Rheumatoid Arthritis

Abstract

Due to reports that these medicines are secure and have minimal unfavourable side effects, particularly when compared to produced pharmaceuticals, interest in using medicinal plants has gradually grown in poor countries in recent years. In the present study, simple, efficient, and economical silver nanoparticles (AgNPs) were produced using the leaf extracts of the three herbs Vitex negundo, Ehretia laevis and rhizomes of Curcuma amada. This multi-herb extract was transformed into synthetic AgNPs, which were more active than the original extract. After synthesising the polyherbal extract and its AgNPs the nanogel was made using a few gelling agents, and the resulting silver nanoparticles nanogel formulation was evaluated.  The anti-arthritic characteristics of the recently discovered topical polyherbal nanogel formulation may be due to luteolin, which is present in methanol extracts of polyherbal silver nanoparticles. It was found that the newly developed formulation F2, which contains 1.5% of carbopol 934 and 2% of the three herb extracts, is a potential topical polyherbal nanogel for the management of arthritis. The effectiveness of this formulation for persons with inflammatory joint conditions may be further supported by clinical studies.