Exploring Cocrystals: Preparation Tactics, Advantages, And Formation Mechanisms
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Abstract
The low solubility profile of drugs is one of the most demanding characteristics in drug dosage development, restraining the bioavailability of any drug. Based on solubility and permeability profiles, drugs are categorized into four different groups by the biopharmaceutical Classification system (BCS), which provides guidance optimization of dosage form for any drug. Many formulation methods for solubility enhancement of drugs having low solubility have been prepare. While they have shown fruitful results in enhancing drug bioavailability effectively, outcomes of these methods are based on certain physicochemical conditions of that molecule. Some of these methods have been discussed in this article. The preferred drug formulation for the majority of APIs continues to be oral dosage forms. Pharmaceutical co-crystals are a cutting-edge approach for increasing the bioavailability of low-solubility drugs in oral dosage form by boosting solubility, micrometric properties, dissolution rate, and stability. Co-crystals are the combination of an active pharmaceutical ingredient and one or more pharmaceutically accepted guest molecules called coformer in a stoichiometric ratio in a crystal lattice. In the current scenario, the solubility profile of drugs is a leading concern in drug development in pharma industry. This review paper offers a thorough examination of pharmaceutical cocrystals, encompassing preparation techniques, physicochemical characteristics, and practical uses. It serves as a valuable resource for improving the design and production of pharmaceutical cocrystals with specific physicochemical traits and intended applications, providing valuable insights for their efficient development
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References
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