Investigation Of The Etiological Structure And Sensitivity Of Pathogens To Antibacterial Drugs In Patients With Various Forms Of Pyelonephritis
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Abstract
Pyelonephritis is an infectious inflammatory kidney disease. One of the main directions of treatment of this disease is antibiotic therapy. But recently, due to the excessive, unjustified and inadequate use of antibiotics, the problem of antibiotic resistance of pathogens has manifested itself. In this regard , measures are being developed for the rational and effective use of antibiotics in medicine. Therefore , monitoring of resistance and updating of epidemiological data deserves special attention. Goal: investigation of the etiological structure of pyelonephritis with the establishment of the sensitivity of pathogens to appropriate antibacterial drugs. 68 medical records with a diagnosis of pyelonephritis were analyzed. The most common pathogens of acute and chronic pyelonephritis were E. coli, which was isolated in 87.5±4.8% of the studied patients. High sensitivity of Escherichia coli to carbapenems (imepenem/cilastatin), cephalosporins (ceftriaxone, cefotaxime, cefaperazone) was determined.
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References
Sinyakova L.A. Retsidiviruyushchiye infektsii mochevykh putey: slozhnosti up- roshchennoy diagnostiki. [Recurrent Urinary Tract Infections: the Complexity of a Simplified Diagnosis] / L.A. Sinyakova // Urologiya segodnya [Urology Today]. — 2013. — 1. — P. 3-7. [in Russian]
Kameneva O.A. Etiologicheskaya struktura i antibiotikorezistentnost' vozbuditeley vnebol'nichnykh infektsiy mochevyvodyashchikh putey v Sankt-Peterburge, 2013-2015. [Etiological Structure and Antibiotic Resistance of Pathogens of Community-Acquired Infections of the Urinary Tract in St. Petersburg, 2013-2015] / O.A. Kameneva, S.E. Morozova, O.E. Punchenko [et al.] // Antibiotiki i khimioterapiya [Antibiotics and Chemotherapy]. — 2017. — 62(9-10). — P. 19-26. [in Russian]
Palagin I.S. Sovremennoye sostoyaniye antibiotikorezistentnosti vozbuditeley vnebol'nichnykh infektsiy mochevykh putey v Rossii: rezul'taty issledovaniya «DARMIS» (2010-2011). [Current State of Antibiotic Resistance of Pathogens Causing Community- Acquired Urinary Tract Infections in Russia: "DARMIS" Study (2010–2011)] / I.S. Palagin, M.V. Suhorukova, A.V. Dekhnich [et al.] // Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya [Clinical Microbiology and Antimicrobial Chemotherapy]. — 2012. — 14(4). — P. 280-302. [in Russian]
Lokshin K.L. Sovremennoye sostoyaniye antibiotikorezistentnosti i sostav vozbuditeley infektsiy mochevykh putey u beremennykh [The Current State of Antibiotic Resistance and the Composition of Pathogens of Urinary Tract Infections in Pregnant Women] / K.L. Lokshin, V.N. SHirshov, A.S. Popko [et al.] // Vestnik urologii [Bulletin of Urology]. — 2018. — 6(2). — P. 13-20. — DOI: 10.21886/2308-6424-2017-6-2-13-20. [in Russian]
Gupta K. International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 update by the infectious diseases society of America and the European Society for Microbiology and Infectious Diseases / K. Gupta, T.M.Hooton, K.G. Naber [et al.] // Clin Infect Dis. — 2011. — 52(5). — P. e103-20. — DOI: 10.1093/cid/ciq257.
Bonkat G. EAU Guidelines on Urological Infections / G. Bonkat, R. Pickard, R. Bartoletti [et al.] — URL: https://uroweb.org/wp-content/uploads/EAU-Guidelines- on-Urological-Infections-2018-large-text.pdf (accessed 13.11.2023).
Lopatkin N.A. Rossijskie nacional'nye rekomendacii "Antimikrobnaya terapiya i profilaktika infekcij pochek, mochevyvodyashchih putej i muzhskih polovyh organov [Russian National Recommendations "Antimicrobial Therapy and 3 Международный научно-исследовательский журнал ▪ № 2 (140) ▪ Февраль Prevention of Infections of the Kidneys, Urinary Tract and Male Genital Organs"] / N.A. Lopatkin, O.I. Apolihin, D.YU. Pushkar' [et al.] — M., 2014. [in Russian]
Sukhorukova M.V. Antibiotikorezistentnost' nozokomial'nykh shtammov Enterobacteriaceae v statsionarakh Rossii: rezul'taty mnogotsentrovogo epidemiologicheskogo issledovaniya MARAFON v 2011–2012 gg [Antimicrobial Resistance of Nosocomial Acinetobacter spp. Isolates in Russia: Results of National Multicenter Surveillance Study "MARATHON" 2011- 2012] / M.V. Suhorukova, M.V. Ejdel'shtejn, E.YU. Skleenova [et al.] // Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya [Clinical Microbiology and Antimicrobial Chemotherapy]. — 2014. — 16(4). — P. 266-272. [in Russian]
Kuz'michev B.YU. Analiz antibiotikorezistentnosti u bol'nykh urologicheskogo profilya. [Analysis of Antibiotic Resistance in Patients with Urological Profile] / B.YU. Kuz'michev, E.A. Orlova, A.R. Umerova [et al.] // Kontsept [Concept]. — 2016. — 15. — P. 676–680. [in Russian]
Zsolt F. Hospital-Acquired Infections / F. Zsolft // Causes and Control. — London: Philadelphia: Whurr. Publishers, 2002. — P. 289.