Design, Synthesis, And In Vitro Antibacterial, Cytotoxic, And Antifungal Studies For New Substitutes 2-Amino-4-Aryl-7-Propargyl Oxy-4H-Chromene-3-Carbonitriles By Effective Click Chemistry
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Abstract
A three-step procedure using sodium carbonate as a catalyst was used to manufacture a series of 2-amino-7-hydroxy-4H-chromene-3-carbonitriles 4a-c. The solvent mixture used in the experiment was 96% ethanol and water, with a volume ratio of 1:20. A successful reaction between the corresponding hydroxyl chromenes derivatives and propargyl bromide resulted in the propargyl ether compounds 5a–c, which are derived from chromene-3-carbonitriles. 5a–c propargyl ethers and 1-azido-3-chlorobenzene were linked by 1H-1,2,3-triazole-tethered click chemistry to produce 4H-chromene-chlorophenyl conjugates 7a–c. The ideal catalyst for this chemical reaction was CuI. From 77.68% to 82.33%, the yields of 1H-1,2,3-triazole were measured. The antimicrobial activity of each of the triazoles 7a-c was examined in vitro. The following compounds were found to be efficient against several bacteria: B. subtilis (MCC 2010), S. aureus (MCC 2408), P. aeruginosa (MCC 2408), and E. coli (MCC 2412).
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References
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