Formulation And Evaluation Of Preformulation Studies And Precompressional Parameters Of Anti Hypertensive Drug Losartan Potassium By Using Locust Bean Gum As Superdisintegrant
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Abstract
Fast dissolving drug delivery systems offers a solution for those patients having difficulty in swallowing tablets/capsules etc. Fast dissolving tablets disintegrate instantaneously in the mouth so that they can be swallowed without the aid of water. The aim of the present study was to investigate pre formulation studies of drug losartan potassium using locust bean gum as a natural super disintegrant. Perform pre formulation studies like partition coefficient, solubility and identification of drug. The influence of precompressional parameters like angle of repose, swelling index and micromeritic properties on formulation of a tablet along with melting point, drug characterization like organoleptic properties, interaction studies and compatibility
Material and methods: Losartan potassium was received as gift sample from Elfin drug pvt ltd baddi, nalagarh (Himachal Pradesh). Locust bean gum was purchased fromLucid colloids, Mumbai. Microcrystalline cellulose (avice1102), aspartame and magnesium stearate was received as gift sample from helios pharmaceutical pvt. ltd. baddi (H.P). Menthol was purchased from Yarrow Chem. Mumbai (Maharashtra) and talc was purchased from Qualichems Fines Chemicals ltd New Delhi.
Result: The results suggested that locust bean gum in 7.5% concentration possess excellent super disintegrant property and resulted in fast dissolving tablets. Swelling index was found to be 22 which indicated appreciable capability of locust bean gum to be used as super disintegrant. IR spectra and DSC study showed that there was no any kind of interaction with formulation additives of the tablets.
Conclusion: Based on the pre formulation studies locust bean gum show a super disintegrant properties and it is clear that we can formulate fast dissolving antihypertensive tablet with losartan potassium by using locust bean gum as superdisintegrant.
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References
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