Correlation Between Obesity And Sexual Precocity Of Pre-Pubertal Girls In The Republic Of Dagestan
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Abstract
Introduction: The original article considers obesity as a factor of premature development in girls due to the relevance of this problem in our time. [1] Gonadotropin-dependent (central, or true), gonadotropin-independent and partial forms are distinguished. Gonadotropin-dependent premature sexual development (GPR) is associated with activation of the central link of the hypothalamic-pituitary-gonadal system.[2],[3] The cause may be tumors of the chiasmal cell region, organic lesions of the central nervous system, genetic disorders..[4] Gonadotropin-independent PPD is caused by the secretion of sex steroids by gonads or tumors of the gonads or adrenal glands, excessive production of androgens by the adrenal glands due to steroidogenesis disorders. Partial forms represent an isolated enlargement of the mammary glands in girls and an isolated development of puberty. [5] Leptin and adiponectin of adipose tissue act on the hypothalamo-pituitary system and activate GnRH. The hormone initiates the production of FSH and LH of the pituitary gland, which have their effects on peripheral organs.[6],[7] It is also noted that peers are ahead of their physical development at the very beginning, but later, due to the early closure of the epiphyses, stunting is also often observed. [8],[9]
Objectives: To discover the connection between high BMI in the pre-puberty period and premature puberty of girls. Brooke C.G.D., Brown R.S. in the book "Guide to pediatric endocrinology." they write: "Direct measurements of body fat (hydrodensitometry, BIA or DEXA) are interesting, but BMI (weight in kilograms divided by the square of height in meters) is easy to calculate and correlates adequately with direct indicators, so BMI is often used to determine obesity.[10]
Methods: Based on the case histories of patients from hospitals in many cities and districts of the republic, this problem was studied.
Results: The result of the study showed that there is a direct relationship between premature telarche, pubarche and menarche and BMI > 85%. In conclusion, we want to confirm once again the existence of this relationship in children. It is necessary to observe the diet, eliminate physical inactivity in girls to prevent obesity and the development of this pathology, and in the future metabolic syndrome and PCOS. [11]
Conclusions: It was found in this study that the risk of developing PPD increases if a girl is obese of the 1st degree. It is necessary to continue studying girls with obesity of 2 and 3 degrees in order to obtain more information and discover the relationship between BMI and PPD. Lifestyle modification is recommended for younger children – restriction of sweet, fatty foods, the use of hard-to-digest carbohydrates, proteins, as well as the prevention of physical inactivity.
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References
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