Green Synthesis Of Benzimidazole Analogues: An Overview
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Abstract
Green chemistry gives importance to procedures of synthesis according to its well-known 12 principles, contributing to the sustainability, energy savings, lesser toxicity of reagents, intermediates and final products, lesser damage to the environment and human health, decreasing the risk of global warming, and more rational use of natural resources and agricultural wastes. In recent years, various heterocyclic compounds have synthesized owing to the extensive varieties of their pharmacological activities. Benzimidazole is an important Pharmacophore and privileged structure in medicinal chemistry which exhibits various therapeutic activities like antiulcer, antihypertensive, analgesic, antiviral, antifungal, antibacterial, anticancer, antihistaminic, anti-diabetic and anti-inflammatory. Because of its medicinal potential, the processes for their synthesis have become a focus of synthetic chemists. Therefore, this review focuses at compiling the chemistry of differently substituted benzimidazoles and greener methods.
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References
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