Potential Role of Silver Nanoparticles of Pterospermum acerifolium Plant Extract in Alzheimer disease
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Abstract
Stress is the key factor of the physiological change & deformity of the cell that leads to degeneration of the cell. Degeneration of the brain cells is the main cause of dementia this pathological condition also known as Alzheimer's disease (AD). The characteristics of AD are disorientation in thinking and liberation in individual daily activities in old age. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease. Pterospermum acerifolium, basic plant in India, is viewed as carminative, stimulant, and emmenagogue. The improvement of control discharge conveyance systems could prompt huge preferences in the clinical employments of these medications to diminish the toxicities. The point of this study was to figure another conveyance framework for impacts of neurochemicals by the joining of concentrate of P. acerifolium into strong lipid nanoparticles (SLNs). Nanotechnology has given the likelihood of conveying medications to particular cells utilizing nanoparticles. Nano systems can convey the dynamic constituent at an adequate fixation amid the whole treatment time frame, guiding it to the fancied site of activity. Traditional medications do not meet these necessities. The fundamental motivation behind creating elective medication conveyance advancements is to expand effectiveness of medication conveyance and security during the time spent medication conveyance and give more accommodation to the patient, nano formulations were prepared by Ethanolic extract, silver nanoparticle were pictured by checking scanning electron microscopy. Particle size and size distribution were dictated by photon connection spectroscopy.
Results and Discussion: The change of molecule charge was contemplated by zeta potential estimations. Treatment with plant extract and nanoparticle was found to altogether diminish the serum levels of nitrite/ nitrates, Super oxide anions, GSH, TBARS and SOD . it also gives the beneficial effect on the learning memory, retention time and escaping time measured in the animal model of Morris water
Conclusion: The outcomes got from this study recommended that the memory‑improving impact of nanoparticle with concentrate was interceded through directions of neurochemical and neuroendocrine frameworks.
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References
Ahsan, S. M., Rao, C. M., & Ahmad, M. F. (2018). Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona. Advances in experimental medicine and biology, 1048, 175-198.
Bir, S. C., Khan, M. W., Javalkar, V., Toledo, E. G., & Kelley, R. E. (2021, August). Emerging Concepts in Vascular Dementia: A Review. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 30(8), 105864.
Boateng, F., & Ngwa, W. (2019, December). Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications. International journal of molecular sciences, 21(1).
Ceriello, A., & Prattichizzo, F. (2021, May). Variability of risk factors and diabetes complications. Cardiovascular diabetology, 20(1), 101.
Chang Wong, E., & Chang Chui, H. (2022, June). Vascular Cognitive Impairment and Dementia. Continuum (Minneapolis, Minn.), 28(3), 750-780.
Chen, X., Liu, Y., Liu, X., & Lu, C. (2022, November). Nanoparticle-based single molecule fluorescent probes. Luminescence : the journal of biological and chemical luminescence, 37(11), 1808-1821.
Cloete, L. (2022, January). Diabetes mellitus: an overview of the types, symptoms, complications and management. Nursing standard (Royal College of Nursing (Great Britain) : 1987), 37(1), 61-66.
Darenskaya, M. A., Kolesnikova, L. I., & Kolesnikov, S. I. (2021, May). Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bulletin of experimental biology and medicine, 171(2), 179-189.
Devi, K. P., Malar, D. S., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017). A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin. Current drug targets, 18(13), 1529-1536.
Frederiksen, K. S. (2017, March). [Vascular dementia]. Ugeskrift for laeger, 179(12).
Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014, November). Nanoparticle approaches against bacterial infections. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 6(6), 532-47.
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016, March). The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine (London, England), 11(6), 673-92.
Huang, J., Chen, Y.-j., Bian, W.-h., Yu, J., Zhao, Y.-w., & Liu, X.-y. (2010, May). Unilateral amyloid-beta25-35 injection into the rat amygdala increases the expressions of aberrant tau phosphorylation kinases. Chinese medical journal, 123(10), 1311-4.
Iadecola, C. (2013, November). The pathobiology of vascular dementia. Neuron, 80(4), 844-66.
Ilievski, V., Zuchowska, P. K., Green, S. J., Toth, P. T., Ragozzino, M. E., Le, K., . . . Watanabe, K. (2018). Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PloS one, 13(10), e0204941.
Jelinkova, P., Mazumdar, A., Sur, V. P., Kociova, S., Dolezelikova, K., Jimenez, A. M., . . . Adam, V. (2019, August). Nanoparticle-drug conjugates treating bacterial infections. Journal of controlled release : official journal of the Controlled Release Society, 307, 166-185.
Jiang, C.-S., Ru, T., Yao, L.-G., Miao, Z.-H., & Guo, Y.-W. (2019, July). Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-Aβ aggregation activities. Fitoterapia, 136, 104176.
Kalaria, R. N. (2018, May). The pathology and pathophysiology of vascular dementia. Neuropharmacology, 134(Pt B), 226-239.
Korczyn, A. D., Vakhapova, V., & Grinberg, L. T. (2012, November). Vascular dementia. Journal of the neurological sciences, 322(1-2), 2-10.
Kumar, M., Sabu, S., Sangela, V., Meena, M., Rajput, V. D., Minkina, T., . . . Harish. (2022, December). The mechanism of nanoparticle toxicity to cyanobacteria. Archives of microbiology, 205(1), 30.
Li, H., Wang, P., Huang, F., Jin, J., Wu, H., Zhang, B., . . . Wu, X. (2018, February). Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice. Toxicology and applied pharmacology, 340, 58-66.
Li, X., Peng, X., Zoulikha, M., Boafo, G. F., Magar, K. T., Ju, Y., & He, W. (2024, January). Multifunctional nanoparticle-mediated combining therapy for human diseases. Signal transduction and targeted therapy, 9(1), 1.
O'Brien, J. T., & Thomas, A. (2015, October). Vascular dementia. Lancet (London, England), 386(10004), 1698-706.
Portacolone, E. (2018). On Living Alone with Alzheimer's Disease. Care weekly, 2018, 1-4.
Rundek, T., Tolea, M., Ariko, T., Fagerli, E. A., & Camargo, C. J. (2022, January). Vascular Cognitive Impairment (VCI). Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 19(1), 68-88.
Sen, S., & Chakraborty, R. (2015). Treatment and Diagnosis of Diabetes Mellitus and Its Complication: Advanced Approaches. Mini reviews in medicinal chemistry, 15(14), 1132-3.
Sun, Y., Tao, Q., Wu, X., Zhang, L., Liu, Q., & Wang, L. (2021). The Utility of Exosomes in Diagnosis and Therapy of Diabetes Mellitus and Associated Complications. Frontiers in endocrinology, 12, 756581.
Suzuki, C., Yokote, Y., & Takahashi, T. (2015, January). Changes in daily cognition and behavior of Alzheimer's patients over time: a three-year evaluation using a daily cognition and behavior for Alzheimer's disease scale. Dementia (London, England), 14(1), 126-35.
Tohgi, H. (1990, August). Vascular dementia. The Tohoku journal of experimental medicine, 161 Suppl, 39-47.
Volicer, L., Stelly, M., Morris, J., McLaughlin, J., & Volicer, B. J. (1997, September). Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. International journal of geriatric psychiatry, 12(9), 913-9.
Wolters, F. J., & Ikram, M. A. (2019, August). Epidemiology of Vascular Dementia. Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1542-1549.
Zeng, H., Li, P., Zhou, L., & Ding, K. (2020, October). A novel pectin from Polygala tenuifolia blocks Aβ(42) aggregation and production by enhancing insulin-degradation enzyme and neprilysin. International journal of biological macromolecules, 161, 35-43.
Zeyfang, A., Wernecke, J., & Bahrmann, A. (2023, February). Diabetes Mellitus at an Elderly Age. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 131(1-02), 24-32.
Zhang, S., Gao, H., & Bao, G. (2015, September). Physical Principles of Nanoparticle Cellular Endocytosis. ACS nano, 9(9), 8655-71.
Zhang, Y.-N., Poon, W., Tavares, A. J., McGilvray, I. D., & Chan, W. C. (2016, October). Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. Journal of controlled release : official journal of the Controlled Release Society, 240, 332-348.
Zhao, B. (2005). Natural antioxidants for neurodegenerative diseases. Molecular neurobiology, 31(1-3), 283-93.