Anticancer Activity Of Nanosuspension Of Extract Of Malaxis Acuminata On Breast Adenocarcinoma Cell Line (MCF-7 Cell Line) And Hepatocellular Carcinoma Cell Line (Hep G2 Cell Line) – An In Vitro Study
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Abstract
The cytotoxic activity of Malaxis Acuminata Nanosuspension (MANS) was evaluated using the MTT assay on two cancer cell lines: MCF-7 (breast adenocarcinoma) and Hep G2 (hepatocellular carcinoma). The study measured cell viability at various concentrations of Malaxis Acuminata Nanosuspension and compared it to the standard chemotherapeutic agent Doxorubicin. For MCF-7 cells, the IC50 value of Malaxis Acuminata Nanosuspension was 63.97 µg/mL, indicating a moderate cytotoxic effect, while Doxorubicin had an IC50 value of 1.81 µg/mL, demonstrating a higher efficacy. Similarly, for Hep G2 cells, Malaxis Acuminata Nanosuspension exhibited an IC50 value of 71.6 µg/mL, compared to Doxorubicin's IC50 value of 2.23 µg/mL. The results suggest that MANS shows considerable cytotoxicity in both breast and liver cancer cell lines, though Doxorubicin was more potent. Malaxis Acuminata Nanosuspension holds promise as a potential therapeutic agent for cancer treatment, particularly as a natural-based alternative.
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