A Study To Evaluate Efficacy Of Homoeopathic Remedy Gymnema Sylvestre In 6th Centesimal Potency In The Patients Suffering From Type 2 Diabetis Melitus - A Prospective Observational Study

Abstract

Background: World Health Organization report shows that 300 million people may suffer from Diabetes up to 2025 in which 79 million people from India. Diabetes mellitus (DM) states to a group of common metabolic disorders that share the phenotype of hyperglycemia due to reduced insulin secretion, decreased glucose utilization or increased glucose production. Some distinct types of DM are caused by a complex interaction of genetics and environmental factors. Most common is Type 2 Diabetes Mellitus in which body does not make enough insulin or does not properly utilize it. People living with Type-2 DM are more vulnerable to various forms of complications, both short-term and long-term, which often lead to their premature death. Homoeopathy, a common form of alternative medicine is used worldwide and plays a major role in healing of different diseases. Due to minimal side-effects, homoeopathic remedies may serve as potential method of treatment and in the management of diabetes. Gymnema sylvestre, in various homoeopathic preparations, have reported beneficial effect for treating in Type-2 diabetes mellitus. This study proposed to explore the role of an organ remedy Gymnema sylvestre in reducing the blood sugar level and improving the quality of life of such patients suffering from type 2 DM.

Aim and Objective: To evaluate the efficacy of Gymnema sylvestre in 6CH potency in Type-2 diabetes mellitus patients to improve the QoL of the patients suffering from Type-2 diabetes mellitus.

Materials and Method: This prospective, open label, observational trial, conducted at OPD and IPD of Shaheed Raja Hari Prasad Mall Government Homoeopathic Medical College and Hospital, Barhalganj-Gorakhpur (U.P.) and camps organized by various departments and hospital itself. A total 100 pre-diagnosed cases were enrolled for this study considering all ethical criteria, inclusion and exclusion criteria’s as per ICD-10. Data were recorded on standard case proforma, and entered Microsoft® Excel worksheet 2019, and exported into SPSS v29.0 (IBM, USA) for statistical analysis. Each case was followed up for a period of 12 months. The result of post- treatment outcome in each patient was assessed on the basis of collected pre and post FBS, PPBS, HbA1C, DM score and QoL (Part-1) & QoL (Part-2) values was tested by Paired ‘T’ test.

Results: Out of 255 screened patients, 100 patients (68 males and 32 females) with type 2 DM were enrolled in the study. 20 left the study, so total 80 patient’s (57 males & 23 females) data analysis was done after a follow-up period of 12 months of treatment. In the 80 Cases of Type 2 DM the pre- mean value of FBS level was 7.51 mmol/l, PPBS level was 11.63 mmol/l and HbA1c % was 8.066 whereas the post- mean values were improved to 6.7 mmol/l, 10.54 mmol/l and 6.656 respectively. The pre- mean DM assessment score was 8.0, QoL (Part- 1) was 3.8 and QoL (Part-2) was 5.7, whereas post-mean value improved to 1.6, 4.7 and 5.9 respectively after the end of the treatment of the study population.

Conclusion: Homoeopathic preparations of Gymnema sylvestre in 6CH potency is proved to effective in management of diabetes mellitus is confirmed through the study. The medicine was also helped to improve the quality of life of the patients.