Effectiveness of Liposomal Curcumin on Postoperative Sequelae Following Lower Third Molar Surgery: A Randomized Controlled Clinical Trial

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Published: Dec 25, 2022
DOI: https://doi.org/10.53555/jrtdd.v5i2.3296
Keywords:
Liposomal curcumin pain swelling trismus third molar surgery

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Dr Nitin Bhagat
Dr Rohit Punga

Abstract

Objective: This study aims to assess the efficacy of liposomal curcumin in managing postoperative sequelae such as pain, swelling, and trismus following lower third molar surgery.


Methods: In a randomized controlled trial, patients undergoing third molar extraction were divided into two groups: one receiving liposomal curcumin and the other receiving standard postoperative care. Primary outcomes included pain, swelling, and trismus, while secondary outcomes focused on wound healing quality and infection rates. Statistical analyses determined significance between groups.


Results: Liposomal curcumin significantly reduced pain and swelling at 24, 48, and 72 hours postoperatively compared to the control group. Improved trismus and wound healing were observed in the curcumin group, with no adverse effects reported.


Conclusion: Liposomal curcumin shows potential as an adjunct for reducing postoperative sequelae following lower third molar extractions, suggesting it could enhance postoperative recovery protocols.

Article Details

How to Cite
Dr Nitin Bhagat, & Dr Rohit Punga. (2022). Effectiveness of Liposomal Curcumin on Postoperative Sequelae Following Lower Third Molar Surgery: A Randomized Controlled Clinical Trial. Journal for ReAttach Therapy and Developmental Diversities, 5(2), 514–516. https://doi.org/10.53555/jrtdd.v5i2.3296
Issue
Vol. 5 No. 2 (2022): July-December 2022
Section
Articles
Author Biographies

Dr Nitin Bhagat

Associate Professor and PhD Scholar, Dept of Oral and Maxillofacial surgery, School of dental sciences, Sharda University, Greater Noida

Dr Rohit Punga

Prof and Head, Dept of Oral and Maxillofacial surgery, School of dental sciences, Sharda University, Greater Noida

 

References

Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin against cancer, cardiovascular, pulmonary, and neurological diseases. Int J Biochem Cell Biol. 2009;41(1):40-59.

Parihar A, Eubank TD, Doseff AI. Development and therapeutic potential of liposomal curcumin formulations. J Pharm Pharmacol. 2021;59(1):75-85.

Gonzalez MJ, Miranda-Massari JR, Duconge J. Potential uses of curcumin for various health disorders. Clin Nutr. 2016;35(1):171-177.

Lee Y, Yuk DH, Lee JC. Clinical applications of curcumin in medical treatments. J Oral Maxillofac Surg. 2018;76(1):124-130.

Shishodia S, Sethi G, Aggarwal BB. Curcumin: Getting back to the roots. Ann N Y Acad Sci. 2005;1056:206-217.

Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin”: From kitchen to clinic. Biochem Pharmacol. 2008;75(4):787-809.

Zeng M, Cao X, Shi Y. Liposomal delivery of curcumin enhances its therapeutic efficacy in various diseases. Mol Pharmaceutics. 2020;17(1):50-60.

Banerjee M, Tripathi LM, Srivastava VM. Modulation of inflammatory mediators by curcumin in models of inflammation. Inflammopharmacology. 2003;11(4):373-385.

Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation of endothelial cells and angiogenesis. Cancer Biol Ther. 2005;4(6):516-521.

Panahi Y, Sahebkar A, Parvin S. Efficacy of curcumin formulations in improving inflammation. Phytother Res. 2014;28(7):943-948.

Jurenka JS. Anti-inflammatory properties of curcumin. Altern Med Rev. 2009;14(2):141-153.

Chainani-Wu N. Safety and anti-inflammatory activity of curcumin. J Altern Complement Med. 2003;9(1):161-168.

Aggarwal BB, Sundaram C, Malani N. Curcumin: The Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.

Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol. 2009;133(2):145-151.

Ahn J, Lee J, Seo J. Curcumin’s effectiveness on various inflammatory disorders. Nutr Rev. 2017;75(10):759-770.

Epstein J, Sanderson IR, Macdonald TT. Curcumin as a therapeutic agent. Proc Nutr Soc. 2010;69(3):265-269