“Synthesis Of Energy Efficiency Microwave Assisted Novel 1, 4, 5- Triphenyl Substituted Pyrrole Derivatives”

Main Article Content

Dr. Amit Panaskar
Dr. Bhagyashri Panaskar
Dr. Nagnath R. Kadam
Dr. Surajmal G. Malpani
Mrs. Shwetnisha V. Mande
Dr. Kotresh Yaligar

Abstract

Innovative series of 1, 4, 5 triphenyl substituted pyrrole derivatives have been synthesized using environment friendly procedure and evaluated for their antimicrobial activity. Neat reaction on microwave irradiation resulted in enhancement of yields and reaction rates. Pyrrole derivatives are more potent and possesses less side effects. Benzoin and primary aromatic amine refluxing in ethanol resulted in the formation of α- aminoketone intermediates, that are condensed without isolation with malononitrile to yield various 2-amino-4, 5- diphenyl-1-substituted-1H-pyrrole-3-carbonitriles (1). Pyrrole (1) further reacted with triethyl orthoformate and alcoholic sodium hydroxide gives respective pyrrole derivatives (1a- 1b). The synthesized compound were confirmed through spectral characterization using IR (JASCO 4100-FT/IR), Mass (QP 2013 Shimadzu) and H1 NMR. Result indicate that microwave method is more eco-friendly than conventional method and compound shows promising antimicrobial activity.

Article Details

How to Cite
Dr. Amit Panaskar, Dr. Bhagyashri Panaskar, Dr. Nagnath R. Kadam, Dr. Surajmal G. Malpani, Mrs. Shwetnisha V. Mande, & Dr. Kotresh Yaligar. (2023). “Synthesis Of Energy Efficiency Microwave Assisted Novel 1, 4, 5- Triphenyl Substituted Pyrrole Derivatives”. Journal for ReAttach Therapy and Developmental Diversities, 6(1), 2267–2270. https://doi.org/10.53555/jrtdd.v6i1.3360
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Articles
Author Biographies

Dr. Amit Panaskar

Padmini College of Pharmacy, Dighanchi, India

Dr. Bhagyashri Panaskar

Padmini College of Pharmacy, Dighanchi, India

Dr. Nagnath R. Kadam

Shriganesh Ramchandra Katruwar College of Pharmacy, Manwath, India

Dr. Surajmal G. Malpani

Shivlingeshwar College of Pharmacy, Almala, India.

Mrs. Shwetnisha V. Mande

Shriganesh Ramchandra Katruwar College of Pharmacy, Manwath, India

Dr. Kotresh Yaligar

Padmini College of Pharmacy, Dighanchi, India

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