Exploring the Therapeutic Potential of Boswellia serrata Derivatives in Arthritis: A Molecular Docking Study
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Abstract
Docking is the process to understand interactions between any two molecules. It includes using multiple software and the pre-processing the protein and ligands according to need. Computationally we can screen multiple ligands weather they can be used as potential drug or drug targets in curing a disease. In this paper we’ll discuss about the Boswelliaserrataand its oleo gum resin extracts. Its extract has many components like diterpenoids, tripernoids and different kind of Boswellic acids. While going through the pathway of Rheumatoid Arthritis and Osteoarthritis, we took some protein candidates and docked them against the known compounds and Boswellic acids of oleo resin gum. Multiple docking scores were generated and observing them we can say that it can be a potential drug against arthritic activities. It has the potential to block many proteins of the arthritis and reducing inflammation and relief pain. The docking scores were not that good but if the compounds are modified or developed as candidate then multiple ways can be found to treat or even cure some cases of arthritis. Though, the reason and solid proof is still unknown for osteoarthritis but the symptoms can be treated by using the oleo gum resin of Boswelliaserrata
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References
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