Bioactive Compounds In Grape Seed Extract: Nutritional Composition And Pharmacological Insights
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Abstract
Grape (Vitis vinifera) seed extract is a rich source of bioactive compounds that exhibit numerous health benefits. This study explores the nutritional composition of grape seed extract and its pharmacological properties, emphasizing its antioxidant, anti-inflammatory, antimicrobial, and cardioprotective effects. The presence of polyphenols, flavonoids, and proanthocyanidins contributes significantly to its therapeutic potential. In vitro studies have demonstrated its efficacy in combating oxidative stress, modulating metabolic disorders, and enhancing overall health. This review provides a comprehensive analysis of the bioactive components and their pharmacological implications, supporting the potential of grape seed extract as a natural health supplement.
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References
Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., & Pruess, H. G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148(2-3), 187-197.
Forester, S. C., & Waterhouse, A. L. (2009). Metabolites of anthocyanins following oral administration to rats. Journal of Agricultural and Food Chemistry, 57(9), 4140-4147.
Shi, J., Yu, J., Pohorly, J. E., & Kakuda, Y. (2003). Polyphenolics in grape seeds-biochemistry and functionality. Journal of Medicinal Food, 6(4), 291-299.
Yilmaz, Y., & Toledo, R. T. (2004). Major flavonoids in grape seeds and skins: Antioxidant capacity of catechin, epicatechin, and gallic acid. Journal of Agricultural and Food Chemistry, 52(2), 255-260.
Nassiri-Asl, M., & Hosseinzadeh, H. (2009). Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytotherapy Research, 23(9), 1197-1204.
Xu, Y., Simon, J. E., Welch, C., Wightman, J. D., Ferruzzi, M. G., & Ho, L. (2011). Survey of polyphenol constituents in grapes and grape-derived products. Journal of Agricultural and Food Chemistry, 59(19), 10586-10593.
Zafrilla, P., Ferreres, F., & Tomas-Barberan, F. A. (2001). Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids in raspberry jam. Journal of Agricultural and Food Chemistry, 49(9), 4818-4822.
Terra, X., Valls, J., Vitrac, X., Mérrillon, J. M., Arola, L., Ardévol, A., & Bladé, C. (2007). Grape-seed procyanidins act as anti-inflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFκB signaling pathway. Journal of Agricultural and Food Chemistry, 55(11), 4357-4365.
Xie, P., Huang, L., Zhang, C., & Zhang, Y. (2013). Hypoglycemic and hypolipidemic effects of proanthocyanidin from grape seed in diabetic rats. Food & Function, 4(1), 89-96.
Engle, T. E., Spears, J. W., Armstrong, T. A., Wright, C. L., & Odle, J. (2000). Effects of dietary copper source and concentration on carcass characteristics and lipid and cholesterol metabolism in growing and finishing steers. Journal of Animal Science, 78(4), 1059-1065.
Zillich, O. V., Schweiggert-Weisz, U., Eisner, P., & Kerscher, M. (2015). Polyphenols as active ingredients for cosmetic products. International Journal of Cosmetic Science, 37(5), 455-464.
Xia, E. Q., Deng, G. F., Guo, Y. J., & Li, H. B. (2010). Biological activities of polyphenols from grapes. International Journal of Molecular Sciences, 11(2), 622-646.
van der Sluis, A. A., Dekker, M., de Jager, A., & Jongen, W. M. (2001). Activity and concentration of polyphenolic antioxidants in apple: Effect of cultivar, harvest year, and storage conditions. Journal of Agricultural and Food Chemistry, 49(8), 3606-3613.