Comparative Study On The Efficacy Of Different Crystalloid Solutions In The Management Of Diabetic Ketoacidosis
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Abstract
Diabetic ketoacidosis (DKA) is a very serious complication of diabetes and is elaborated as hyperglycemia, ketosis and acidosis. It has been linked with big morbidity and mortality rates making its treatment very quick and efficient. The main intervention that is applied when managing DKA is the restoration of the acidotic state by intravenous (i.v.) fluid resuscitation. Normal Saline (NS), Ringer Lactate (RL) and Plasmalyte (PL) are popular examples of crystalloids because of their low costs. This research sought to appraise how these three fluids affect levels of serum electrolytes, anion gap, blood pH, and resolution of DKA in the patients. One hundred and fifty patients with the diagnosis DKA were randomly spaced into three groups (50 patients in each arm). Normal saline was administered to the patients in Group A (NS), Ringer lactate to the patients in Group B (RL), whereas plasmalyte was administered to the patients in Group C (PL). Serum electrolytes and blood pH level examination were done on a baseline and every hour, 8 hours. The findings showed that Plasmalyte (PL) was associated with the greatest improvement in metabolic acidosis, it had an increased decrease in serum chloride with a faster rate of recovery as compared to normal saline and Ringer lactate. Although both normal saline and Ringer lactate were regarded as significant in changing serum bicarbonate levels, Plasmalyte had a better rate in acidosis correction as well as electrolyte metion misbalance. It is believed that the best fluid to use to treat DKA is Plasmalyte since it proves significantly faster to recover and exhibit fewer electrolyte imbalances than normal saline and Ringer lactate. In this study, the possible benefits of using Plasmalyte in the resuscitation of fluids in patients with DKA are indicated.
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References
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