Ayurveda-Based Supportive Care Using Guduchi, Ashwagandha, and Curcumin for Breast Cancer Patients: A Pilot Observational Study on Quality of Life and Safety

Abstract

Background: Breast cancer is the most common malignancy among women worldwide. While modern therapies improve survival, treatment-related side effects often impair quality of life (QoL). Complementary interventions, including Ayurveda, may offer supportive benefits, but clinical evidence is limited.

Objective: To evaluate the effect of an Ayurveda-based regimen—Guduchi (Tinospora cordifolia), Ashwagandha (Withania somnifera), and Curcumin (Curcuma longa)—on QoL and safety in breast cancer patients receiving conventional therapy.

Methods: Forty women at IMS-BHU, Varanasi, were allocated to supportive (n=20) or control (n=20) groups. The supportive group received standardized formulations alongside conventional therapy; controls received conventional therapy alone. QoL was assessed at baseline and 8 weeks using Hindi versions of EORTC QLQ-C30 and QLQ-BR45. Safety was monitored via laboratory tests and CTCAE v5.0.

Results: Supportive patients reported higher global health status (75.0 vs. 41.7), physical (86.7 vs. 60.0) and emotional functioning (62.5 vs. 44.2), and lower symptom burden for pain and insomnia. QLQ-BR45 indicated better body image, fewer breast symptoms, reduced systemic therapy side effects, lower endocrine symptoms, and less hair loss distress (all p < 0.05). No serious adverse events occurred; two patients reported mild, self-limiting gastric discomfort.

Conclusion: Ayurveda-based supportive care with Guduchi, Ashwagandha, and Curcumin may safely improve QoL in breast cancer patients receiving conventional therapy. Larger trials are warranted.