Hemocompatibility of Copper oxide with BSA for osteoblast application.
Main Article Content
Abstract
The improvement of the physical structure and biological activity of biomaterials is significantly influenced by copper oxide. As a trace element in the human body, copper (Cu) not only possesses antibacterial properties and a range of biological functions but also has the capability to promote angiogenesis. In comparison to growth factors, copper offers multiple advantages. It could be utilized in conjunction with other inorganic ions to create new intelligent biomaterials that simulate the bone microenvironment. The aim of this study is to evaluate the hemocompatibility of Copper Oxide with BSA for osteoblast application.
Materials and Methods: CuO nanoparticles were prepared by precipitation method using copper nitrate. 100mg of Bovine serum albumin (BSA) protein powder was added. SEM, FTIR and cell viability was assessed. The control taken was blood with a buffer. ‘S’ represents blood with the sample. Statistical analyses were performed to determine the significance of results.
Results:The scanning electron microscopy study indicates that the morphology was identified as rod-shaped and measured at 1μ in size. A viability of approximately 95.4% was observed in cells regarding cell attachment and toxicity. Improved cell attachment and proliferation were noted.
Conclusion: The study concludes that the prepared copper oxide nanoparticle with BSA was found to be highly compatible and can be taken up for bone regeneration applications.
Article Details
References
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