Galactan as a filler to prevent biofilm formation - An in-silico approach
Main Article Content
Abstract
INTRODUCTION: Oral biofilm is a virulence factor in many oral infectious diseases, including dental caries, gingivitis, periodontitis, periapical periodontitis, and peri-implantitis. Implanted biomaterials (such as Gutta-percha points) provide a surface for bacterial adhesion and biofilm formation, ultimately leading to biomaterial infections. Galactan is a polysaccharide that is made up of polymerized galactose. They are found in red seaweeds and are commercially important due to their widespread use as gelling and thickening agents in the food industry. Assessment of these polysaccharides as a filler or a sealant in endodontic purposes can be a boon for the dental industry as they have gelation and thickening properties and are derived from a natural source.
AIM: This study is to analyse the effects of galactan used as a filler and in the prevention of biofilm formation.
MATERIALS AND METHODS:
RESULTS:
DISCUSSION:
CONCLUSION:
Article Details
References
Melo MA. Bacterial Interactions with Dental and Medical Materials. MDPI; 2021. 248 p.
Huang R, Li M, Gregory RL. Bacterial interactions in dental biofilm. Virulence. 2011 Sep 1;2(5):435–44.
Paster BJ, Olsen I, Aas JA, Dewhirst FE. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000. 2006;42:80–7.
Berger D, Rakhamimova A, Pollack A, Loewy Z. Oral Biofilms: Development, Control, and Analysis. High Throughput [Internet]. 2018 Aug 31;7(3). Available from: http://dx.doi.org/10.3390/ht7030024
Siqueira JF Jr, Rôças IN, Favieri A, Abad EC, Castro AJ, Gahyva SM. Bacterial leakage in coronally unsealed root canals obturated with 3 different techniques. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):647–50.
Lau PCY, Dutcher JR, Beveridge TJ, Lam JS. Absolute quantitation of bacterial biofilm adhesion and viscoelasticity by microbead force spectroscopy. Biophys J. 2009 Apr 8;96(7):2935–48.
Pradhan B, Rout L, Ki JS. Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan. Carbohydr Polym. 2023 Feb 1;301(Pt A):120326.
Zhang S, Wang Y, Li Y, Miao L, Wang K. Modulation of poly (acrylic acid) hydrogels with κ-carrageenan for high-performance quasi-solid Al-air batteries. Int J Biol Macromol [Internet]. 2022 Dec 8; Available from: http://dx.doi.org/10.1016/j.ijbiomac.2022.12.050
