Correlation of Vitamin-D with Disease Severity and Psychological Effect in Rheumatoid Arthritis Patients

Abstract

Vitamin Dis either directly absorbed from food or produced in the skin behind exposure to UVB rays. In the kidneys and liver, Vitamin Dis hydroxylated to create 1,25(OH)2D, which has been demonstrated to have potent immunomodulatory characteristics. Rheumatoid arthritis (RA) and other autoimmune illnesses have been linked to Vitamin Ddeficiency, and it is thought to have anti-inflammatory and immunomodulatory characteristics. Significant treatment implications arise from the hypothesis that the severity of RA is associated with serum Vitamin Dlevels. The anti-inflammatory effects of Vitamin Dare expected to be refereed at sites of RA disease, notably the inflamed joint. The active form of vitamin D, 1,25-dihydroxy vitamin D3 (1,25(OH)2D3), may be implicated in these actions. This study compares a study with 100 volunteers, 50 RA sufferers and 50 healthy controls, all of whom were between the ages of 18 and 75. Vitamin Dserum levels have been measured and compared between patients and controls. Levels of Vitamin Din RA patients were also examined at various steps of disease activity to ascertain whether there is an association between the two where 84% of RA patients reported Vitamin Ddeficiency compared to 34% of controls. In “RA patients serum Vitamin Dlevels” are also significantly lower than in the controls. There was a strong inverse connection between Vitamin Dlevels in serum and RA disease activity.

Patients with osteoarthritis (OA) experience negative effects on their mental health. In addition to their physical symptoms, people with rheumatoid arthritis (RA) may also suffer psychological difficulties such as worry and sadness. It is clear that the central nervous system can be impacted through both psychological stress & persistent inflammatory illnesses. Long-term exposure to high amounts of cytokines such as “tumour necrosis factor (TNF)”, IL-6, and IL-1 in RA may result in inappropriate behaviours such as anhedonia, anorexia, fatigue, and depression as a result of disease.