A New Spectra Method for Estimation and Evaluation of the Gabapentin Drug in Antiepileptic Pharmaceuticals

Abstract

Gabapentin in bulk powder and prescription dose form can now be measured using a brand-new spectrophotometric method, which was just created. It's easy to use, accurate, and cheap. The method was tested and a variety of dosage forms were examined. It is Fe(II) that oxidises Gabapentin at pH 4.0 when it comes into contact with iron ions (acetate buffer). 355 nm is the maximum absorption wavelength of the colouredeques medium. At optimal concentrations, Beer's law and the concentration range of 2.0-12.0 g mL-1 had a significant relationship coefficient (0.9998). The detection limit was found to be 1.22 ng mL-1, while the detection limit was discovered to be 3.40 ng mL-1. Sandell's sensitivity of 0.3889 x 10-11 g/cm2 and the molar absorption coefficient of 1.182608 x 104 Lmol-1/cm-1 combine to give us a value of 0.3889 x 10-11 g/cm2. The International Conference on Harmonization's recommendations were followed when evaluating the procedure's validity. To ensure that the method is suitable for routine gabapentin analysis, it was successfully used to estimate drug concentrations in pharmaceutical dose forms without influence from additives.