Cinacalcet Benefits in Chronic Kidney Disease Patients in Babylon Province

Abstract

Introduction: Cinacalcetis calcium sensetive receptor and professionallyreductionsparathyroid hormone (PTH). The aim of study is to assessed the effect of Cinacalcet on the level of PTH, serum calcium and phosphate in patients they have CKD and on maintenance hemodialysis.

Method:Cross sectional experimental study of 60 patients with chronic kidney disease, group A; 30 patients on maintenance hemodialysis not receive cinacalcet 60 mg daily at night for 6 months’ group B; 30 patients also on maintenance hemodialysis receive cinacalcet 60 mg daily at night for 6 months’. Patients age gender were taken, also measured the serum calisuim (Ca⁺⁺), phosphate and parathyroid hormone levels.

Results:. Mean age of patients in group A (50.83 ± 14) years, while group B (48.9 ± 15) years with no significant difference. There is significant difference in mean of serum Ca⁺⁺level between group A and group B. There is significant difference in mean of serum phosphatelevel between group A and group B. There is significant difference in mean of parathyriodhormone level between group A and group B.

Conclusion:The serum Ca⁺⁺ level decrease in patients received cinacalcet, serum phosphate and parathyriod hormone levelsdecreasein patients received cinacalcet.