Role of Expression of Leptin Receptors in Ovarian Cancer in Babylon Province

Abstract

Background: one of the incessant gynecological tumors is ovarian cancer, with most of patients being analyzed at a late stage. The five-year survive around 30%. Generally, it present at late stage, with a low survival probability, due to a lack of good screening tools. The objective: study the association of deregulated leptin receptor-mediated signaling with ovarian tumor.

Methods: In this case, control study, which involved 140 participants, 100 patients with ovarian tumor and 40 control. The Automated Slide Stainer (Ventana Discovery XT) was used to stain IHC.Specimens stained for LEPR were digitized at 20.

Results: There was significant difference among them regarding expression of leptin receptor (p<0.05). There was significant difference between malignant form and controls (p<0.05) but insignificant difference between benign and borderline type and control group (p>0.05).72.5% with Ovarian cancer had positive leptin receptor while only 40% in control group. Multinomial regression was done, negative leptin IHC had significant lower odds ratio in Serous Epithelial Ovarian Cancer when compared with healthy control. Negative leptin signal had protective effect for Serous Epithelial Ovarian Cancer (odds ratio =0.246, [0.095-0.638]). Borderline tumor and Benign Ovarian Tumor had also lower odds ratio for negative leptin IHC (p>0.05). Absence of leptin receptor had protective role from ovarian cancer.

Conclusion: Elevated levels of leptin receptors have been associated to an increased risk of ovarian cancer.These findings could aid in the development of ovarian cancer screening and treatment options.