Vitamin D Levels In Patients With Epilepsy
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Abstract
The current burden of epilepsy is very high in India with nearly 12 million people suffering from epilepsy at a mean prevalence of 1 percent .1Low levels of Vitamin D levels are seen in patients with epilepsy Antiepileptic drugs used for seizure control have also been known to cause Vitamin D deficiency especially as they are used over prolonged periods of time.3
Plasma levels of 25 hydroxy cholecalciferol are significantly lower in patients on antiepileptic drugs as compared to normal adults and adolescents with no difference in dietary intake or exposure to sunlight.2,3
Hypovitaminosis of Vitamin D is linked to several brain disorders including cognitive decline, epilepsy, affective disorders and schizophrenia.4 Vitamin D has alsobeen reported to potentiate the anticonvulsant activity of conventional antiepileptic drugs.5
Moreover, Vitamin D deficiency prevails in epidemic proportions all over the Indian subcontinent, with a prevalence of 80%–90 % of the general population.6 currently there is a dearth of studies in this area hence current study was done
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References
Gururaj, G., Satishchandra, P., &Amudhan, S. (2015). Epilepsy in India I: Epidemiology and public health. Annals of Indian Academy of Neurology, 18(3), 263. https://doi.org/10.4103/0972-2327.160093
Alhaidari, Hussam Mohammed, et al. “Association Between Serum Vitamin D Levels and Age in Patients With Epilepsy: A Retrospective Study From an Epilepsy Center in Saudi Arabia.” Annals of Saudi Medicine, vol. 42, no. 4, King Faisal Specialist Hospital and Research Centre, July 2022, pp. 262–68. Crossref,
https://doi.org/10.5144/0256-4947.2022.262.
Teagarden, Diane L., et al. “Low Vitamin D Levels Are Common in Patients With Epilepsy.” Epilepsy Research, vol. 108, no. 8, Elsevier BV, Oct. 2014, pp. 1352–56. Crossref, https://doi.org/10.1016/j.eplepsyres.2014.06.008.
Stewart A1, Wong K, Cachat J, Elegante M, Gilder T, Mohnot S, Wu N, Minasyan A, Tuohimaa P, Kalueff AV. Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology. BehavPharmacol. 2010 Sep;21(5-6):420-6.
Holló A, Clemensemail Z, Kamondi A, Lakatos P, Szűcs A. Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study; Epilepsy &Behavior, May 2012; 24(Issue 1): 131–133.
Gupta, SanjeevKumar, et al. “Vitamin D Deficiency in India.” Journal of Family Medicine and Primary Care, vol. 7, no. 2, Medknow, 2018, p. 324. Crossref, https://doi.org/10.4103/jfmpc.jfmpc_78_18.
Djibuti M, Shakarishvili RInfluence of clinical, demographic, and socioeconomic variables on quality of life in patients with epilepsy:findings from Georgian study J NeurolNeurosurg Psychiatry 2003;74:570–573
Harinarayan CV, Joshi SR. Vitamin D status in India—its implications and remedial measures. J Assoc Physicians India 2009;57:40–48.
Kulak Carolina A.M., BorbaVictória Z.C., Bilezikian John P., Silvado Carlos E., Paola Luciano de, Boguszewski César L.. Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs. Arq. Neuro-Psiquiatr. [Internet]. 2004 Dec [cited 2016 Nov 18] ; 62( 4 ): 940-948.
Shellhaas RA, Barks AK, Joshi SM. Prevalence and risk factors for vitamin D insufficiency among children with epilepsy. Pediatric neurology. 2010;42(6):422-426. doi:10.1016/j.pediatrneurol.2010.03.004.
S Nagarjunakonda, S Amalakantil, V Uppala, L Rajanala and S AthinaVitamin D in epilepsy: vitamin D levels in epilepsy patients, patients on antiepileptic drug polytherapy and drug-resistant epilepsy sufferers European Journal of Clinical Nutrition 2016;70:140–142.
Mithal. A. Wahl D.A. , Bonjour J.-P.. Burckhardt P. Dawson-Hughes B. Eisman J.A., El-Hajj Fuleihan G., Josse R. G.,Lips P. & Morales-Torres J.Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int Nov 2009;20(11): 1807–1820.
Christiansen, C., Rødbro, P., &Sjö, O. . “Anticonvulsant Action” of Vitamin D in Epileptic Patients? A Controlled Pilot Study. British Medical Journal 1974; 2(5913): 258–259.
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. Journal of Clinical Investigation. 1985;76(4):1536-1538.
Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology. 2012;79:1397–405.
doi: 10.1212/WNL.0b013e31826c197f.
Gough H, Goggin T, Bissessar A, Baker M, Crowley M, Callaghan N.A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.Q J Med. 1986 Jun;59(230):569-77.
Davie MW , Lawson DE , Emberson C , Barnes JL , Roberts GE , Barnes ND . Vitamin d from skin : contribution to vitamin d status compared with oral vitamin D in normal and anticonvulsant treated subjects . Clin sci (lond) 1982:63:461-72
Mithal. A. Wahl D.A. , Bonjour J.-P.. Burckhardt P. Dawson-Hughes B. Eisman J.A., El-Hajj Fuleihan G., Josse R. G.,Lips P. & Morales-Torres J.Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int Nov 2009;20(11): 1807–1820.
Mishal, A.A., Effects of Different Dress Styles on Vitamin D Levels in Healthy Young Jordanian Women. Osteoporosis International, 2001;12(11): 931-935.