Antidiarrheal And Acute Toxicity Study Of Ethanolic Extract Of Pyrus Pashia In Swiss Albino Mice

Abstract

Diarrheal remains a major health concern in underdeveloped nations, causing millions of deaths and billions of episodes annually, according to the World Health Organization. This study investigated the antidiarrheal potential of Pyrus Pashiain ethanolic fruit extract using Wistar albino mice, with concurrent assessment of acute toxicity. The ethanolic extract exhibited significant antidiarrheal activity, reducing the defecation rate by up to 78.33% at 600 mg/kg, comparable to loperamide (100%). The mechanism involves denaturing proteins and forming protein tannates, reducing intestinal mucosa permeability. The LD50 for the ethanolic fruit extract was determined to be 10,715 mg/kg, indicating its safety. This study validates the traditional use of Pyrus Pashiain ethanolic fruit extract as a herbal remedy for diarrheal, showcasing both its efficacy and safety, contributing to the exploration of natural treatments for this prevalent health issue