A Review On Medicinal Plants Uses For Various Types Of Cancer
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Abstract
Cancer is a perilous and rapidly advancing disease. Cancer has now become the primary cause of mortality in the country, surpassing cardiovascular disease, and ranks as the second most common cause of death globally. Many cancer patients are looking for alternative or complementary treatments because of the high mortality rate associated with cancer as well as the negative effects that chemotherapy and radiation therapy can have on their bodies. Exploring medicinal plants for treating various illnesses, including cancer, is the foundation of traditional medicine, with a history spanning a century. Traditional medicine utilizes plants with bioactive components to treat and prevent ailments. Plants have significantly contributed to the industrialization of the pharmaceutical industry globally. This overview includes various medicinal plants known for their potent anticancer properties, as well as the specific anticancer compounds present in these plants. The article offers crucial information for researchers aiming to create a safe and non-toxic cancer treatment using medicinal plants. This research attempts to establish a scientific basis for the traditional usage of these medicinal herbs in cancer treatment. No cancer therapy now available has been demonstrated to be entirely successful and free of risks, despite the variety of drugs used to address many forms of cancer. The first concern that needs to be dealt with is the toxicity of the drugs currently used in cancer treatment. Clinical research has shown that plants and plant-derived medications are effective and safe for treating and managing cancers.
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References
American Cancer Society. Cancer Facts & Figures. Atlanta: American Cancer Society; 2010.
Boivin JF. Second Cancers and Other Late Side Effects of Cancer Treatment. Cancer 1990;65(S3):770-5.
Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, Issell B, Kirshner JJ, Colman LK. Prevalence of complementary and alternative medicine use in cancer patients during treatment. Support Care Cancer. 2005;13(10):806-11.
Sri PU, Sree NV, Revathi S, Kumar YVVA, Sri ND. Role of herbal medicines in cancer. Int J Pharm Sci Res. 2010;1(11):7-21.
Devmurari VP, Pandey S, Goyani MB, Jivani NP, Marotrao S, Sivakumar P. Evaluation of Anticancer Activity of Adiantum venustum (Don). Int J PharmacogPhy Res. 2010;2(1):5-10.
Mubashir S, Shah WA. Phytochemical and Pharmacological Review Profile of Adiantum venustum. Int J Pharm Tech Res. 2011;3(2):827-30.
Gul MZ, Bhakshu LM, Ahmad F, Kondapi AK, Qureshi IA, Ghazi IA. Evaluation of Abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays. BMC Complement Altern Med. 2011;11(1):64.
Kohn LK, Pizao PE, Foglio MA, Antonio MA, Amaral MCE, Bittric V et al. Antiproliferative activity of crude extract and fractions obtained from Aspido-sperma tomentosum Mart. Rev Bras Pl Med Botucatu. 2006;8(esp):110-5.
Andrea L, Holguin MF, Holguin O, Micheletto S, Goehle S, Julian A, Mary A, Connell O. Chemotypic Variation of Essential Oils in the Medicinal Plant Anemopsis californica. Phytochemistry. 2008;69(4):919-27.
Catherine N, Seth KL, Lowrey T, Guerra L, Slambrouck SV, Wim FA. In vitro anticancer activity of Anemopsis californica. Oncol Lett. 2010;1(4):711-15.
Childs RF, Cole JR. Phytochemical and pharmacological investigation of Anemopsis californica. J Pharm Sci. 1965;54(5):789-91.
Laizuman N, Ronok Z, Ashik M, Saiful I, Anamul H, Abul F, Mele J. Antioxidant and antitumor activity of chloroform extract of Alangium salvifolium flowers. Phytopharmacol. 2012;2(1):123-34.
Ronok Z, Badrul AM, Saiful IM, Gopal SC, Nargis CS, Salman HB, Mosaddik MA, Mele J Ekramul HM. Anticancer activity of Alangium salvifolium flower in Ehrlich ascites carcinoma bearing mice. J Cancer Res. 2011;7(3):254-62.
Sharma AK, Agarwal V, Kumar R, Balasubramaniam A, Mishra A, Gupta R. Pharmacological studies on seeds of Alangium salvifolium linn. Acta Poloniae Pharmaceutica Drug Res. 2011;68(6):897-904.
Prasad L, Khan TH, Tamanna J, Sarwat S. Acorus calamus extracts and nickel chloride, prevention of oxidative damage and hyperproliferation response in rat kidney. Biol Trace Elem Res. 2006;113(1):77-91.
Rajkumar V, Guha G, Kumar AR, Mathew L. Evaluation of cytotoxic potential of Acorus calamus rhizome. Ethnobotanical Leaflets. 2009; 13:832-9.
Gyawali R, Kim K. Volatile organic compounds of medicinal values from Nepalese Acorus calamus. J Sci Engg Tech. 2009;5(2):51-65.
Palani S, Raja S, Kumar RP, Venkdesan D, Devi K, Sivaraj A, Senthil BK. Therepeutic efficacy of antihepatotoxic and antioxidandt activities of Acorus calamus on acetaminophen- induced toxicity in rats. Int J Integr Biol. 2009;7(1):39-44.
Singh, R, Sharma, PK, Rishabha M. Pharmacological Properties and ayurvedic value of Indian buch plant (Acorus calamus): A Short Review. Adv Biol Res. 2011;5(3):145-54.
Kuete V, Vouffo B, Mbaveng AT, Vouffo EY, Siagat RM, Dongo E. Evaluation of Antiaris africana methanol extract and compounds for antioxidant and antitumor activities. Pharm Biol. 2009;47(11):1042-9.
Vouffo B, Etienne D, Petrea F, Andrea T, George S, Armin M, et al. Antiaroyl cinnamate and africanoside, a cinnamoyl triterpene and a hydroperoxy-cardenolide from the stem bark of Antiaris Africana. Planta Medica. 2010;76(15):1717-23.
Rabi T, Karunagaran D, Nair MK, Bhattathiri VN. Cytotoxic activity of amooranin and its derivatives. Phytother Res. 2002;16(S1):84-6.
Rabi T, Liming W, Banerjee S. Novel triterpenoid 25-hydroxy-3-oxoolean-12- en-28-oic acid induces growth arrest and apoptosis in breast cancer cells.Breast Cancer Res Treat. 2007;101(1):27-36.
Rabi T, Ramachandran C, Fonseca HB, Nair RPK, Alamo A, Melnick SJ, Escalon E. Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines. Breast Cancer Res Treat. 2003;80(3):321-30.
Chan LL, Sherine G, Irfan A, Saujanya GL, Atiya A, Cunningham BT, Watkin KL. Cytotoxicity effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evid Based Complement Alternat Med. 2011; Article ID 860605, 8 pages.
Cheppail R, Thangaiyan R, Fonseca HB, Steven MJ, Enrique AE. Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines. Int J Cancer. 2003;105(6):784-9.
Rabi T, Banerjee S. Novel semisynthetic triterpenoid AMR-Me inhibits telomerase activity in human leukemic CEM cells and exhibits in vivo antitumor activity against Dalton’s lymphoma ascites tumor. Cancer Lett. 2009;278(2):156-63.
Thangapazham RL, Singh AK, Seth P, Misra N, Mathad VT, Raj K, et al. Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells. Front Biosci. 2008;13:561-8.
Bibi Y, Nisa S, Zia M, Waheed A, Ahmed S, Chaudhary MF. Adenocarcinoma Cell Line (MCF-7) and phytochemical analysis. Pak J Pharm Sci. 2012;25(1):183-7.
Zhang Z, Li S, Lian XY. An overview of genus aesculus L.: Ethnobotany, Phytochemistry, and Pharmacological activities. Pharm Crops. 2010;1:24-51.
Jagetia GC, Venkatesh P, Baliga MS. Aegle marmelos (L.) Correa Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice. Biol Pharm Bull. 2005;28(1):58-64.
Lampronti ID, Martello N, Bianchi M, Borgatti E, Lambertini R, Piva S, et al. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine.2003;10(4):300-8.
Gangadevi V, Muthumary J. Taxol, an anticancer drug produced by an endophytic fungus Bartalinia robillardoides Tassi, isolated from a medicinal plant, Aegle marmelos Correa ex Roxb. World J Microbiol Biotechnol. 2008;24(5):717-24.
Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, et al. Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene Carboxaldehyde, a Novel Compound from Aegle marmelos. Cancer Res. 2008;68(20):8573-81.
Khan TH, Sultana S. Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study. Toxicol Mech Methods. 2011;21(6):453-62.
Islam MS, Kusumoto Y, Al-Mamun MA. Cytotoxicity and Cancer (HeLa) Cell Killing Efficacy of Aqueous Garlic (Allium sativum) Extract. J Sci Res. 2011;3(2):375-82.
Thomson M, Ali M. Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets. 2003;3(1):67-81.
Karmakar S, Choudhury SR, Banik NL, Swapan RK. Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma. Anticancer Agents Med Chem. 2011;11(4):398-407.
Shukla Y, Kalra N. Cancer chemoprevention with garlic and its constituents. Cancer Lett. 2007;247(2):167-81.
Guruvayoorappan C, Kuttan G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pacific J Cancer Prev. 2007;8(1):27-32.
Bhaskar VH, Rajalakshmi V. Anti-tumor activity of aqueous extract of Biophytum sensitivum Linn. Annals Biol Res. 2010;1(3):76-80.
Guruvayoorappan C. Apoptotic Effect of Biophytum sensitivum on B16F-10 Cells and Its Regulatory Effects on Nitric Oxide and Cytokine Production on Tumor Associated Macrophages. Integr Cancer Ther. 2007;6(4):373-80.
Guruvayoorappan C. Biophytum sensitivum (L.) DC Inhibits Tumor Cell Invasion and Metastasis Through a Mechanism Involving Regulation of MMPs, Prolyl Hydroxylase, Lysyl Oxidase, nm23, ERK-1, ERK-2, STAT-1, and Proinflammatory Cytokine Gene Expression in Metastatic Lung Tissue. Integr Cancer Ther. 2008;7(1):42-50.
Cichewicz RH, Kouzi SA. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2004;24(1):90-114.
Chatterjee D, Sahu RK, Jha AK, Dwivedi J. Evaluation of Antitumor Activity of Cuscuta Reflexa Roxb (Cuscutaceae) Against Ehrlich Ascites Carcinoma in Swiss Albino Mice. Trop J Pharm Res. 2011;10(4):447-54.
Suresh V, Sruthi V, Padmaja B, Asha VV. In vitro anti-inflammatory and anticancer activities of Cuscuta reflexa Roxb. J Ethnopharmacol. 2011;134(3):872-7.
Gupta M, Mazumder UK, Kumar RS, Sivakumar T, Vamsi ML. Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci. 2004;94(2):177-84.
Gupta M, Mazumder UK, Rath N, Mukhopadhyay DK. Antitumor activity of methanolic extract of Cassia fistula L. seed against Ehrlich Ascites Carcinoma. J Ethnopharmacol. 2000;72(1):151-6.
Rejiya CS, Cibin TR, Annie A. Leaves of Cassia tora as a novel cancer therapeutic-An in vitro study. Toxicol in Vitro. 2009;23(6):1034-8.
Bala A, Kar B, Pallab KH, Mazumdar UK, Bera S. Evaluation of anticancer activity of Cleome gynandra Ehrlich Ascites Carcinoma treated mice. J Ethnopharmacol. 2010;129(1):131-4.
Chul PB, Kefa BO, Eung-Seok L, Soo LY, Jung-Ae K. Asiatic Acid Induces Apoptosis in SK-MEL-2 Human Melanoma Cells. Cancer Lett. 2005;218(1):81-90.
Cho CW, Choi DS, Cardone MH, Kim CW, Sinskey AJ, Rha C. Glioblastoma cell death induced by asiatic acid. Cell Biol Toxicol. 2006;22(6):393-408.
Heidari M, Heidari-Vala H, Sadeghi MR, Akhondi MM. The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo. J Nat Med. 2012;66(2):271-8.
Rai N, Agrawal RC, Khan A. Chemopreventive Potential of Centella asiatica on B6F10 Melanoma Cell Lines in Experimental Mice. Pharmacologyonline 2011;1:748-58.
Suboj B, Jose P, Priya PS, Vinod V, Karedath AAT, Priya S, Srinivas G. Apoptosis Induction of Centella Asiatica on Human Breast Cancer Cells. Afr J Trad Complement Altern Med. 2009;6(1):9-16.
Liu S, Luo X, Li D, Zhang J, Qiu D, Liu W, She L, Yang Z. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol. 2006;6(9):1387-93.
Liu S, Zhang J, Li D, Liu W, Luo X, Zhang R, Li L, Zhao J. Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. Nat Prod Res. 2007;21(10):915-22.
Yin Y, Heo S, Wang MH. Antioxidant and Anticancer Activities of Methanol and Water Extracts from Leaves of Cirsium japonicum. J Appl Biol Chem. 2008;51(4):160-4.
Jin Y, Lu Z, Cao K, Zhu Y, Chen Q, Zhu F, Qian C, Pan J. The Antitumor Activity of Homoharringtonine against Human Mast Cells Harboring the KIT D816V Mutation. Mol Cancer Ther. 2010;9(1):211-23.
Meng H, Yang C, Jin J, Zhou Y, Qian W. Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Leuk Lymphoma. 2008;49(10):1954-62.
Ni D, Ho DH, Vijjeswarapu M, Felix E, Rhea PR, Newman RA. Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia. J Exp Ther Oncol. 2003;3(1):47-52.
Bakshi HA, Sam S, Anna F, Zeinab R, Ahmad SG, Sharma M. Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton’s Lymphoma (DLA) in Mice. Asian Pacific J Cancer Prev.2009;10(5):887-90.
Fikrat AI. Cancer Chemopreventive and Tumoricidal Properties of Saffron (Crocus sativus L.). Exp Biol Med. 2002;227(1):20-5.
Kumar PK. Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum Exp Toxicol. 2006;25(2):79-84.
Gomez-Flores R, Martínez HH, Guerra PT, Guerra RT, Licea RQ, Enriqueta CM, Padilla CR. Antitumor and immunomodulating potential of Coriandrum sativum, Piper nigrum and Cinnamomum zeylanicum. J Nat Prod. 2010;3:54-63.
Huang TC, Fu HY, Ho CT, Tan D, Huang YT, Pan MH. Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food Chem. 2007;103(2):434-43.
Singh R, Koppikar SJ, Paul P, Gilda S, Paradkar AR, Ghanekar RK. Comparative analysis of cytotoxic effect of aqueous cinnamon extract from Cinnamomum zeylanicum bark with commercial cinnamaldehyde on various cell lines. Pharm Biol. 2009;47(12):1174-9.
Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R. Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer. 2010;10(1):210.
Csupor-Loffler B, Hajdu Z, Zupko I, Molnar J, Forgo P, Vasas A, Kele Z, Hohmann J. Antiproliferative Constituents of the Roots of Conyza Canadensis.Planta Medica. 2011;77(11):1183-8.
Maneerat W, Tha-in S, Cheenpracha S, Prawat U, Laphookhieo S. New amides from the seeds of Clausana lansium. J Med Plants Res. 2011;5:2812-5.
Prasad KN, Hao J, Yi C, Zhang D, Qiu S, Jiang Y, Zhang M, Chen F. Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel. J Biomed Biotech. 2009; Article ID 612805, 6 pages.
Motta FCM, Santos DYAC, Salatino MLF, Almeida JMD, Negri G, Carvalho JE, Ruiz ALTG, Ines C, Salatino A. Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys. Rev bras farmacogn. 2011;21(6):972-7.
Wang X, Xu J, Yang M, Hong Z. Chloroform extract of Tibetan herbal medicine Dracocephalum tanguticum Maxim. inhibits proliferation of T98G glioblastomas cells by modulating Caspase-3 cleavage and expression of Bax and p21. J Med Plants Res. 2011;5(25):6024-31.
Hu M, Xu L, Yin L, Qi Y, Li H, Xu Y, Han X, Peng J, Wan X. Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways. J Appl Toxicol. 2011;33(8):712-22.
Wang G, Chen H, Huang M, Wang N, Zhang J, Zhang Y, Bai G, Fong WF, Yang M, Yao X. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006;241(1):102-9.
Cibin TR, Srinivas G, Gayathri DD, Priya S, Lija Y, Annie A. Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells. Int J Pharmacol. 2006;2(5):520-4.
Sidambaram RR, Dinesh MG, Jayalakshmi ET. An in Vitro Study of Cytotoxic Activity of Euphorbia Hirta on Hep2 Cells of Human Epithelioma of Larynx. Int J Pharm Pharm Sci. 2011:3(Supple 3):101-3.
Guo Z, Xu Y, Han L, Bo X, Huang C, Ni L. Antioxidant and cytotoxic activity of the acetone extracts of root of Euphorbia hylonoma and its ellagic acid derivatives, J Med Plant Res. 2011;5(23):5584-9.
Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev. 2011;20(3):225-39.
Poojari R, Gupta S, Maru G, Khade B, Bhagwat S. Chemopreventive and Hepatoprotective Effects of Embelin on N-Nitrosodiethylamine and Carbon Tetrachloride Induced Preneoplasia and Toxicity in Rat Liver. Asian Pac J Cancer Prev. 2010;11(4):1015-20.
Yang CJ, Wang CS, Hung JY, Huang HW, Chia YC, Wang PH, Weng CF, Huang MS. Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung Cancer. 2009;66(2):162-8.
Balijepalli MK, Tandra S, Pichika MR. Antiproliferative activity and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cell lines by Gmelina asiatica roots. Pharmacog Res. 2010;2(2):113-9.
Noudeh GD, Sharififar F, Noodeh AD, Moshafi MH, Afzadi MA, Behravan E, et al. Antitumor and antibacterial activity of four fractions from Heracleum persicum Desf. and Cinnamomum zeylanicum Blume. J Med Plants Res. 2010;4(21):2176-80.
Lam SK, Ng TB. Novel galactonic acid-binding hexameric lectin from Hibiscus mutabilis seeds with antiproliferative and potent HIV-1 reverse transcriptase inhibitory activities. Acta Biochimica Polonica. 2009;56(4):649-54.
Lin CC, Kuo CL, Lee MH, Hsu SC, Huang AC, Tang NY, Lin JP, Yang JS, Lu CC, Chiang JH, Chueh FS, Chung JG. Extract of Hedyotis diffusa Willd Influences Murine Leukemia WEHI-3 Cells in vivo as well as Promoting T- and B-Cell Proliferation in Leukemic Mice. In vivo. 2011;25(4):633-40.