Design, Development, And Evaluation of a Polyherbal Formulation for Managing Hepatic Disorders

Abstract

This research delves into the comprehensive evaluation of capsules and soft chewable capsules formulated with extracts from five medicinal plants: Swarnakshiri (Argemone Mexicana Linn.), Haridra (Curcuma longa Linn.), Pipali (Piper longum Linn.), Bhringraj (Eclipta alba (L.) Hassk.), and Guduchi (Tinospora cordifolia (Willd.) Hook. f.). The investigation begins with a thorough morphological and microscopical study to authenticate the selected plants. Subsequently, thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC) profiles are employed to identify the key phytoconstituents in the formulations. Determination of λmax by UV spectrometry provides insights into the absorption characteristics of the herbal extracts. Additionally, drug-drug interaction studies using Fourier Transform Infra-Red (FTIR) spectroscopy ensure the safety and compatibility of the combined formulations. The evaluation of capsules encompasses appearance, dissolution, disintegration, and absence of heavy metals and microbial contamination. Furthermore, nutritional analysis sheds light on the carbohydrate, protein, and cholesterol content in the formulations. Through this systematic approach, the research aims to elucidate the pharmaceutical potential and safety profile of herbal capsules and soft chewable capsules derived from the aforementioned medicinal plants.