Extraction, Isolation And Evaluation Of Anti-Diabetic Activity Of Morus Alba

Abstract

A member of the Moraceae family is the mulberry, or Morus Alba L.  Numerous secondary metabolites have been discovered from Morus Alba Linn, including triterpenoids, flavonol glycosides, anthocyanins, and steroids. The purpose of this study is to evaluate the extract of Morus Alba L. in mice model for potential anti-diabetic effects and preliminary phytochemical screening. Although there is growing evidence regarding the mulberry branch's (MB) ability to prevent diabetes, the main active ingredient in this action is yet unknown. The streptozotocin-induced diabetic ICR mouse was given oral MB ethanol (EtOH) extracts [0.5 or 1 g/ kg body weight (BW)] once a day for 22 days. This drastically decreased the diabetic control mouse's plasma glucose level and fasting blood levels in a dose-dependent manner. Oxyresveratrol [ORT, 0.6 g/kg BW], a primary constituent of MB EtOH extracts, was administered to diabetic ICR mice, which also markedly lowered their fasting plasma glucose level. Moreover, ORT raised the transcription of the hepatic glucose transporter 2 and the amount of glycogen. There was no difference in intestinal disaccharidase activity or plasma insulin levels between the diabetes control and ORT groups. This implies that ORT decreased plasma glucose by promoting the liver's absorption of glucose and storage of glycogen. MB EtOH extracts and ORT may be useful as complementary treatments for the treatment of diabetes.