Development and Assessment of Orodispersible Tablets Utilizing Natural Superdisintegrant.
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Abstract
The current study aimed to develop Diltiazem HCl orodispersible tablets using banana powder as a superdisintegrant by direct compression technique. The powder mixture prepared for compression was evaluated for angle of repose, bulk density, Carr’s index, Hausner’s ratio. Post-compression evaluation of prepared tablet includes drug content, weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration test and in-vitro drug release studies. All parameter produced good results. The drug and excipients were found to be compatible during IR testing. The study reveals that formulation prepared by direct compression F6 exhibits highest dissolution using banana powder at an 8% concentration and showed faster drug release 96.37% over a 25 minute period, while tablet disintegration time was 36 seconds when compared to other formulation batches of Diltiazem HCl.
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References
Arshad MS, Zafar S, Yousef B, Alyassin Y, Ali R. A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing. Advanced drug delivery reviews. 2021; 178, 113840.
Kumar RS, Ghosh A. Fast dissolving tablets: patient compliance dosage forms. World Journal of Pharmacy and Pharmaceutical Sciences. 2019; 8(3): 280-300.
Masih A, Kumar A, Singh S. Fast dissolving tablets: a review. International Journal of Current Pharmaceutical Research. 2017; 9(2): 8-18.
Gupta DK, Maurya A, Varshney MM. Orodispersible tablets: an overview of formulation and technology. World Journal of Pharmacy and Pharmaceutical Sciences. 2020; 9(10): 1406-1418.
Daraghmeh N, Chowdhry BZ, Leharne SA. Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets. Marine drugs. 2015; 13(4): 1739-1764.
Patil HK, Patil GM, Jain VH. A review on mouth dissolving tablet. Journal of Applied Pharmaceutical Research. 2017; 5(2): 09-15.
Aguilar-Díaz JE, Montoya EG, Negre JME, Lozano PP. European Journal of Pharmaceutics and Biopharmaceutics. 2012; 80(3): 638-648.
Hannan PA, Khan JA, Khan A, Safiullah S. Oral dispersible system: a new approach in drug delivery system. Indian Journal of Pharmaceutical Sciences. 2016; 78(1): 2-7.
Schreiner T, Schaefer UF, Loth H. Immediate drug release from solid oral dosage forms. Journal of Pharmaceutical Sciences. 2005; 94(1): 120-133.
Siddiqui MN, Garg G, Sharma PK. Fast dissolving tablets preparation, characterization & evaluation an overview. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4(2): 87-96.
Alam MT, Parvez N, Sharma PK. FDA-approved natural polymers for fast dissolving tablets. Journal of Pharmaceutics. 2014; 1-6.
Reddy MSB, Ponnamma D, Choudhary R, Sadasivuni KK. A comparative review of natural and synthetic biopolymer composite scaffolds. Polymers. 2021; 13(7): 1105.
Ahirwar K, Shukla R. Preformulation studies: a versatile tool in formulation design. Drug Formulation Design. 2023: 1-28.
Nandi K, Sen DJ, Patra F. Angle of repose walks on its two legs: Carr index and Hausner ratio. World Journal of Pharmacy and Pharmaceutical Sciences. 2020; 9(5): 1565-1579.
Jain NK. Industrial Pharmacy-I. 1st edition. Vallabh Prakashan, Delhi; 2021: 52-56.
Thapa C, Chaudhary R. Formulation and in-vitro evaluation of sustained release matrix tablets of domperidone. Journal of Universal College of Medical Sciences. 2020; 08(22): 40-45.
Fand D, Alone S, Jadhav P, Chandanshive H, Babar V. Formulation and evaluation of sustained release matrix tablets of glipizide. International Journal of Creative Research Thoughts. 2022; 10(5): e854-e859.
Taylor KMG, Alton ME. Alton’s Pharmaceutics the design and manufacture of medicines. 6th edition. Elsevier, New Delhi; 2022: 523-524.