Assessment Of Anticarcinogenic Activities Of Endangered Plant Species Of Western Ghats In Cytotoxicity Studies For Mcf-7 Cell Line By Mtt Assay Method

Abstract

Cancer is a major public health problem in most developed countries, and is one of the leading causes of death around the world. The traditional approaches to treat cancer such as surgery, hormone therapy, radiotherapy and chemotherapy methods can cause adverse side effects. With this context, in the current we aimed to evaluate anticarcinogenic activities of endangered plant species of western ghats in cytotoxicity studies for MCF-7 cell line by MTT assay method. Results depicted that extracts of all the four endangered plant species viz. Curcuma zedoaria, Syzygium travancorium, Plectranthus vettiveroides, and Utleria salcifolia have showed increased inhibition activity with increased concentration of the extracts. The leaf extract U. salcifolia and P. vettiveroides exhibited IC₅₀ value of 34.24 µg/ml and 199 µg/ml respectively. While, stem extracts of C. zedoaria and S. travancorium exhibited IC₅₀ value of 289 µg/ml and 73 µg/ml respectively. In conclusion, stem extract of U. salicifolia exhibited low IC50 value, and therefore it showed highly efficient cytotoxic effect than other tested endangered plant species of western ghats viz. C. zedoaria, S. travancorium, and P. vettiveroides. Hence, stem extract of U. salicifolia could be considered for the development of natural anticarcinogenic drugs.