Exploring The Efficacy Of Plant-Based Homeopathic Remedies Against Streptococcal Infections: A Comprehensive Literature Review
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Abstract
This article addresses the potential of plant-based homeopathic treatments in combating Streptococcus species infections amidst the global challenge of antimicrobial resistance (AMR). It highlights the limitations of conventional antibiotics, such as AMR, microbiota disruption, and secondary infections, emphasizing the urgent need for alternative therapies. The review focuses on Psoralea corylifolia and Ailanthus grandulosa, showcasing their antibacterial, anti-inflammatory, and immunomodulatory properties. These remedies, enriched with bioactive compounds like flavonoids and terpenoids, demonstrate mechanisms such as biofilm disruption and immune regulation. Despite promising in-vitro results, challenges such as standardization, clinical validation, and dose-response understanding persist. The document advocates for integrative medicine, combining homeopathy and conventional treatments, and calls for rigorous research and public health initiatives to address Antimicrobial Resistance (AMR),sustainably
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References
Ahmed SK, Hussein S, Qurbani K, Ibrahim RH, Fareeq A, Mahmood KA, et al. Antimicrobial resistance: Impacts, challenges, and future prospects. Journal of Medicine, Surgery, and Public Health [Internet]. 2024;2(100081):100081. Available from: http://dx.doi.org/10.1016/j.glmedi.2024.100081
Lobanovska M, Pilla G. Penicillin’s Discovery and Antibiotic Resistance: Lessons for the Future? Yale J Biol Med. Yale J Biol Med. 2017;90(1):135–45.
Charlotte S. Antimicrobial resistance: a concise update Ho, Charlotte S et al. The Lancet Microbe. 0(0).
Sengupta S, Subhra. Making Homoeopathy an Evidence Based System of Medicine. Importance of Clinical Trials. 2023;49:35–8.
Alaoui Mdarhri H, Benmessaoud R, Yacoubi H, Seffar L, Guennouni Assimi H, Hamam M, et al. Alternatives therapeutic approaches to conventional antibiotics: Advantages, limitations and potential application in medicine. Antibiotics (Basel) [Internet]. 2022;11(12):1826. Available from: http://dx.doi.org/10.3390/antibiotics11121826
Bellavite P. Homeopathy and integrative medicine: keeping an open mind. J Med Person [Internet]. 2015;13(1):1–6. Available from: http://dx.doi.org/10.1007/s12682-014-0198-x
Nabi NG, Shrivastava M. Endangered Medicinal Plant Psoralea corylifolia: Traditional, Phytochemical, Therapeutic Properties and Micropropagation. Pharmaceutical and Biosciences Journal [Internet]. 2017;40–6. Available from: http://dx.doi.org/10.20510/ukjpb/5/i1/147024
Qadir SU, Raja V. Herbal medicine: Old practice and modern perspectives. In: Phytomedicine. Elsevier; 2021. p. 149–80.
Mir AA, Wani GN, Prajapati R, Saklani N, Karuppusamy A, Jha PK, et al. Add-on Psoralea corylifolia mother tincture external application to individualized homeopathic medicines in treatment of vitiligo: Open, randomized, pragmatic, pilot trial. Adv Integr Med [Internet]. 2022;9(1):53–62. Available from: http://dx.doi.org/10.1016/j.aimed.2021.03.003
Aryal S. Haemolysis of Streptococci and its types with examples [Internet]. Microbiology Info.com. Microbiology Info; 2015 [cited 2024 Dec 6]. Available from: https://microbiologyinfo.com/haemolysis-of-streptococci-and-its-types-with-examples/
Forssten SD, Björklund M, Ouwehand AC. Streptococcus mutans, Caries and Simulation Models. Nutrients [Internet]. 2010;2(3):290–8. Available from: http://dx.doi.org/10.3390/nu2030290
Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf [Internet]. 2014;5(6):229–41. Available from: http://dx.doi.org/10.1177/2042098614554919
Grossman TH. Tetracycline antibiotics and resistance. Cold Spring Harb Perspect Med [Internet]. 2016;6(4):a025387. Available from: http://dx.doi.org/10.1101/cshperspect.a025387
Sarah Jividen RN. Everything you need to know about homeopathy and its safety [Internet]. Health. 2024 [cited 2024 Dec 6]. Available from: https://www.health.com/homeopathy-8671301
Schmidt JM. Similia similibus curentur: Theory, history, and status of the constitutive principle of homeopathy. Homeopathy [Internet]. 2021;110(03):212–21. Available from: http://dx.doi.org/10.1055/s-0041-1725061
Mishra R, Dwivedi B. Complementary or alternative plant based medicines and its active constituents responsible for overall therapeutic efficacy. In: Medicinal Plants - Chemical, Biochemical, and Pharmacological Approaches. IntechOpen; 2024.
Homeopathy [Internet]. NCCIH. [cited 2024 Dec 6]. Available from: https://www.nccih.nih.gov/health/homeopathy
Gray BM, Stevens DL. Streptococcal infections. In: Bacterial Infections of Humans. Boston, MA: Springer US; 2009. p. 743–82.
Antimicrobial resistance [Internet]. Who.int. [cited 2024 Dec 6]. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
Álvarez-Martínez FJ, Barrajón-Catalán E, Herranz-López M, Micol V. Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action. Phytomedicine [Internet]. 2021;90(153626):153626. Available from: http://dx.doi.org/10.1016/j.phymed.2021.153626
Koul B, Taak P, Kumar A, Kumar A, Sanyal I. Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology. J Ethnopharmacol [Internet]. 2019;232:201–26. Available from: http://dx.doi.org/10.1016/j.jep.2018.11.036
Chen L, Chen S, Sun P, Liu X, Zhan Z, Wang J. Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics. Chin Med [Internet]. 2023;18(1):4. Available from: http://dx.doi.org/10.1186/s13020-022-00704-6
medicinal herbs: TREE OF HEAVEN - Ailanthus altissima [Internet]. Naturalmedicinalherbs.net. [cited 2024 Dec 6]. Available from: https://naturalmedicinalherbs.net/herbs/a/ailanthus-altissima=tree-of-heaven.php
Liu L, Zhang L, Cui Z-X, Liu X-Y, Xu W, Yang X-W. Transformation of Psoralen and isopsoralen by human intestinal microbial in vitro, and the biological activities of its metabolites. Molecules [Internet]. 2019;24(22):4080. Available from: http://dx.doi.org/10.3390/molecules24224080
Kundu P, Laskar S. A brief resume on the genus Ailanthus: chemical and pharmacological aspects. Phytochem Rev [Internet]. 2010;9(3):379–412. Available from: http://dx.doi.org/10.1007/s11101-009-9157-1
Thounaojam N, Sanjenbam N, Pal S, Singh DK, Kumar K, Shah M. The efficacy of commercially available herbal dentifrices in comparison with conventional dentifrices against two common oral microbes: An in vitro study. J Pharm Bioallied Sci [Internet]. 2021;13(Suppl 1):S176–9. Available from: http://dx.doi.org/10.4103/jpbs.jpbs_635_20
Breijyeh Z, Karaman R. Antibacterial activity of medicinal plants and their role in wound healing. Futur J Pharm Sci [Internet]. 2024;10(1). Available from: http://dx.doi.org/10.1186/s43094-024-00634-0