Genetic Association of ULK4 Gene Polymorphism (Rs1052501) With Susceptibility to Cleft Lip and Palate—A Case Control Study in South Indian Population.

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Published: Nov 30, 2023
DOI: https://doi.org/10.53555/jrtdd.v6i9s(2).3667

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Vignesh M
A. Sumathi Felicita
Vijayashree Priyadharshini Jayaseelan

Abstract

Aim:
To investigate the association between ULK4 gene polymorphism (rs1052501) and susceptibility to cleft lip and palate (CLP).


Methods:
A case-control study was conducted with 25 CLP patients and 25 matched controls. Genotyping of rs1052501 was performed using PCR-RFLP. Statistical analysis included chi-square tests and odds ratios.


Results:
AA genotype was more frequent in cases (88%) than controls (68%), but not statistically significant (p=0.085). An allele also showed higher frequency in cases (0.94 vs. 0.84; p=0.123).


Conclusion:
A potential trend was observed between ULK4 polymorphism and CLP, but no significant association was found. Larger studies are needed to validate these findings.

Article Details

How to Cite
Vignesh M, A. Sumathi Felicita, & Vijayashree Priyadharshini Jayaseelan. (2023). Genetic Association of ULK4 Gene Polymorphism (Rs1052501) With Susceptibility to Cleft Lip and Palate—A Case Control Study in South Indian Population. Journal for ReAttach Therapy and Developmental Diversities, 6(9s(2), 1965–1972. https://doi.org/10.53555/jrtdd.v6i9s(2).3667
Issue
Vol. 6 No. 9s(2) (2023)
Section
Articles
Author Biographies

Vignesh M

Undergraduate student, FINAL YR BDS Student, Saveetha Dental College

A. Sumathi Felicita

Department of Orthodontics, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162 Poonamallee High Road, Chennai 600077, Tami Nadu, India

Vijayashree Priyadharshini Jayaseelan

Chief scientist, Blue Lab - research center, Saveetha dental college and Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai - 600077, Tamil Nadu, India

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