Wound Healing Tissue Graft Using Prf Incorporated Pla Membrane
Main Article Content
Abstract
Poly lactic acid (PLA) is a biocompatible and biodegradable polymer that has been extensively used in tissue engineering and medical devices. Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. Platelet-rich fibrin (PRF) incorporated into a poly(lactic acid) (PLA) membrane is a potential approach for wound healing and tissue grafting.
Materials and methods: This procedure is done by mixing 6% alginate with 3% poly lactic acid and then dissolving it in 100ml of water. And then, freshly platelet rich fibrin is collected from whole blood. These both solutions are mixed together and blended for 3 hours to form a homogenous membrane.
Results and discussion: PLA based composites development is one of the
strategic methods for different problems related diseases. Blending of PLA membrane with PRF may provide balanced physical and biological properties. Platelets, which contain growth factors, play major roles in cell migration, proliferation, differentiation and angiogenesis and are associated with the tissue regeneration process. It can be used as a major method in fabrication of wound healing faster compared to other methods available.
Conclusion: This study concludes that the synthesized PLA with PRF membrane is effective in accelerating wound healing.
Article Details
References
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