Evaluation of Carvacrol Cytotoxicity Depending on Cell Death and Cell Proliferation Markers
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Abstract
Background: Carvacrol is predominant monoterpene presents in the volatile oils of oregano, thyme and some other herbs. It has valuable therapeutic properties that encourage researchers to look into its anticancer activity.
Objectives: The present study was carried out to determine the in vitro cytotoxic and antiproliferative effects of carvacrol on breast cancer cell line.
Materials and Methods: The cytotoxic effect of carvacrol was evaluated by LDH assay. While the antiproliferative effect was assessed as ki-67positive and negative cells. Percentage of growth inhibition was calculated for both tests.
Results: The study clearly showed the cytotoxic and anti-proliferative effect of carvacrol on T47-D cells in dose dependent manner.
Conclusion: These data demonstrated the cytotoxic and antiproliferative of carvacrol on human breast cancer cells, T47-D, and point out that this compound could have a potential therapeutic significance in treating cancer.
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References
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